Team:Tufts

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{{CSS/Main}}
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  <div class="header">
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<img id="logo" src=" " style="max-height: 100px; max-width: 100;"/>
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<div class="heading visible-tablet visible-desktop" style="
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  Tufts University</div>
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    <div class="pull-right" style="text-align:right;">
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      <table border="0">
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            <!--<a href="http://www.iitm.ac.in" target="_blank">
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          <td>
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            <a href="https://2014.igem.org/Main_Page" target="_blank">
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              <img id="igem-logo" src="http://upload.wikimedia.org/wikipedia/en/d/d6/IGEM_official_logo.png" style="width: 129px;">
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          <a href="https://2014.igem.org/Team:Tufts">
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            <i class="icon-home icon-large icon-white"></i>
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            Home
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          </a>
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            <li class="dropdown">
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              <a href="#" class="dropdown-toggle" data-toggle="dropdown">
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                <i class="icon-group icon-large"></i>
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                Team
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                <b class="caret">
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              </a>
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                <li>
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                  <a href="https://2014.igem.org/Team:Tufts/Bios">
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                    Team Bios
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                  </a>
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                </li>
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                <li>
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                  <a href="https://2014.igem.org/Team:Tufts/attributions">
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                    Attributions
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                  </a>
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                  <a target="_blank" href="https://igem.org/Team.cgi?year=2014&team_name=Tufts">
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                    Official Team Profile
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                  </a>
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            <i class="icon-gears icon-large"></i>
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            Project
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            <b class="caret">
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          <ul class="dropdown-menu">
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            <li>
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              <a href="https://2014.igem.org/Team:Tufts/ribosponge">
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                Ribosponge
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              </a>
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            </li>
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            <li>
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              <a href="https://2014.igem.org/Team:Tufts/synenergene">
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                SYNENERGENE Collaboration
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              </a>
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            </li>
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            <li>
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              <a href="https://2014.igem.org/Team:Tufts/medal">
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                Medal Fulfillment
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            </li>
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            <li>
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              <a href="https://2014.igem.org/Team:Tufts/notebook">
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                Notebook
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                Human Practices
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                <b class="caret"></b>
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                  <a href="https://2013.igem.org/Team:Tufts/conference">
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                    The Future of Phage and Synthetic Biology
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                  </a>
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                </li>
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                <li>
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                  <a href="https://2013.igem.org/Team:Tufts/app_scenarios">
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                  Application Scenarios
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                  </a>
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                </li>
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                <li>
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                  <a href="https://2013.igem.org/Team:Tufts/techno-moral_scenarios">
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                  Techno-Moral Scenarios
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                  </a>
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                </li>
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                <li>
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                  <a href="https://2013.igem.org/Team:Tufts/survey">
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                  Survey
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                  </a>
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                </li>
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            <li>
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              <a href="https://2014.igem.org/Team:Tufts/safety">
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                <i class="icon-flag icon-large"></i>
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                Safety
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              </a>
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            </li>
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            <li>
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              <a href="https://2013.igem.org/Team:IIT_Madras/sponsors">
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                <i class="icon-flag icon-large"></i>
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                Sponsors
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              <a target="_blank" href="http://www.facebook.com/iitmigem">
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              <!--<a href="http://twitter.com/junaid_babu">
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         <li data-target="#myCarousel" data-slide-to="2" class=""></li>
         <li data-target="#myCarousel" data-slide-to="2" class=""></li>
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         <li data-target="#myCarousel" data-slide-to="3" class=""></li>
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        <li data-target="#myCarousel" data-slide-to="4" class=""> </li>
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        <li data-target="#myCarousel" data-slide-to="5" class=""> </li>
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       </ol>
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       <div class="carousel-inner">
       <div class="carousel-inner">
          
          
         <div class="item active">
         <div class="item active">
-
           <img src="https://static.igem.org/mediawiki/2013/d/db/Iitm13_Slide_1.jpg" alt="Second slide" style="height: 500px; width: 100%; display: block;">
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           <center><img src=" https://static.igem.org/mediawiki/2014/c/c7/Tufts_phage.jpg" alt="Second slide" style="height: 475px; width: 68%; display: block;"></center>
           <div class="container">
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             <div class="carousel-caption">
             <div class="carousel-caption">
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              <!--<h1>The Team</h1>
 
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              <p>Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
 
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              <p><a class="btn btn-large btn-primary" href="#">More info</a></p>-->
 
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<marquee behavior="scroll" direction="left" style="
 
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">COMBATING SHIGA TOXIN</marquee>
 
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           <img src="https://static.igem.org/mediawiki/2013/f/f5/Iitm13_Slide_2.jpg" alt="Third slide" style="height: 500px; width: 100%; display: block;">
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           <center><img src="https://static.igem.org/mediawiki/2014/0/09/Conf1.jpg" alt="Third slide" style="height: 475px; width: 68%; display: block;"></center>
           <div class="container">
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           <center><img src="https://static.igem.org/mediawiki/2014/e/e7/140310_13187_venter127_%281%29.jpg" " alt="Third slide" style="height: 475px; width: 68%; display: block;"></center>
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          Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to prevent further toxin production by inhibiting the biofilm formation of shigatoxigenic E.coli using indole-3-acetaldehyde (I3A). We expect to validate our approach through functional assays and in silico modelling. Our findings can potentially initiate a new perspective of tackling Shiga toxicosis using synthetic biology tools.
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        Tufts iGEM seeks to expand undergraduate science education and allow students to take part in all aspects of the research process, from drafting proposals, to securing funding, and finally carrying out the research in lab. These projects expose students not only to the technical aspects of synthetic biology but also to the social, legal, and ethical implications generated by their work. The team is composed of passionate individuals from all fields of study, who are driven to investigate and address pertinent issues in medicine, health, technology, research, and bioethics. In addition to carrying out undergraduate, self-directed research, the Tufts iGEM team teaches and mentors underclassmen, develops relationships with professors, and generally works to promote the involvement of undergraduates in biological research.  
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Latest revision as of 01:34, 18 October 2014

Tufts University

Tufts iGEM seeks to expand undergraduate science education and allow students to take part in all aspects of the research process, from drafting proposals, to securing funding, and finally carrying out the research in lab. These projects expose students not only to the technical aspects of synthetic biology but also to the social, legal, and ethical implications generated by their work. The team is composed of passionate individuals from all fields of study, who are driven to investigate and address pertinent issues in medicine, health, technology, research, and bioethics. In addition to carrying out undergraduate, self-directed research, the Tufts iGEM team teaches and mentors underclassmen, develops relationships with professors, and generally works to promote the involvement of undergraduates in biological research.

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