Team:Paris Bettencourt

From 2014.igem.org

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{{Team:Paris_Bettencourt/Wiki}}
 
{{Team:Paris_Bettencourt/Menu}}
{{Team:Paris_Bettencourt/Menu}}
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                                            <!-- Code by the 2014 Paris Bettencourt -->
 +
                                                        <!-- Wiki Wizard :-->
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                                                      <!--HameRyu/MistWalker-->
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 +
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-
 
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 +
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<body>
<body>
<div id=topheader></div>
<div id=topheader></div>
-
<div id=logo><img id=logoblanc src="https://static.igem.org/mediawiki/2014/7/7d/Logoblanc.png"><img id=logorose src="https://static.igem.org/mediawiki/2014/2/28/Logorose.png"></div>
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<div id=logo><img id=logorose src="https://static.igem.org/mediawiki/2014/2/28/Logorose.png"></div>
<div id=subheader>
<div id=subheader>
<div id=definition>
<div id=definition>
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<p class=definition><b>Body malodor has been a problem for humans engaging in social interactions throughout history, and is caused by skin bacteria metabolizing sweat into odorant compounds. Currently, people can either mask body odor with perfumes, or by preventing sweat using an antiperspirant. </b></p>
+
<p class=definition><b>Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few. </b></p>
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<p class=definition>The Paris-Bettencourt iGEM team aims to provide a third, more natural way, to put an end to body malodor using synthetic biology. Currently, there are four ongoing projects targeting armpit, foot, fish, as well as old person odor. The techniques used to eliminate the odor for each case will involve replacing malodorous bacteria and the compounds they produce with non-malodor producing bacteria. The team is also using bacteria to produce a smell database, where primary odors could be combined in bacteria to produce novel smells. The results of this project could go a long way towards helping eliminate body malodor, and allow people confidently engage in social interactions without the influence of bacteria produced malodorous compounds.</p>
+
<p class=definition>The <b>iGEM Paris Bettencourt 2014 </b>project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.</p>
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</div>
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<p class=definition> Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell <i>just like themselves</i>.</p>
 +
 
 +
        <div id=results><a href="https://2014.igem.org/Team:Paris_Bettencourt/Results"><img src="https://static.igem.org/mediawiki/2014/8/85/Gotoresultspb.png"></br><p>Jump To Results</p></a></div>
 +
                        </div>
</div>
</div>
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<div id=sweat></div>
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<div id=smell><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><p class=descript2>Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.</p><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/c/ca/Smelltherosesrose.png" class=nameimgr></a></div>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg></a>
+
                <div class=separation></div>
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<div class=projectdescription></div>
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<div id=fish><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><p class=descript2>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor to appear in the sweat. Here we engineer skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme TMM (trimethylamine monooxygenase).</p><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" id=fishy class=nameimg><img src="https://static.igem.org/mediawiki/2014/f/fd/Somethingfishyrosepb.png" id=fishy class=nameimgr></a></div>
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<div id=smell></div>
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                <div class=separation></div>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg></a>
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<div id=shoes><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><p class=descript2>Isovaleric acid, the cheesy component of foot odor, is produced by <i>B. subtilis</i> through the leucine degradation pathway. We characterize <i>B. subtilis</i> mutants in this pathway, in vitro and in situ (on socks).</p><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/d/dd/Goodytwoshoesrosepb.png" class=nameimgr></a></div>
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<div class=projectdescription></div>
+
                <div class=separation></div>
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<div id=teen></div>
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<div id=sweat><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><p class=descript2>Armpit odor comes mainly from aminoacylase enzymes expressed in the genus <i>Corynebacteria</i>. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.</p><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/a/ac/Dontsweatitrosepb.png" class=nameimgr></a></div>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimgts></a>
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                <div class=separation></div>
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<div class=projectdescription></div>
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<div id=teen><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><p class=descript2>2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.</p><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/5/57/Teenspiritrosepb.png" class=nameimgr></a></div>
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<div id=fish></div>
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                <div class=separation></div>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" class=nameimgsf></a>
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<div class=projectdescription></div>
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<div id=shoes></div>
+
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg></a>
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<div class=projectdescription></div>
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<div class=case1><a href="https://2014.igem.org/Team:Paris_Bettencourt/Mooc"><img src="https://static.igem.org/mediawiki/2014/7/79/Moocv2.png"></a></div>
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<div class=case2><a href="https://2014.igem.org/Team:Paris_Bettencourt/Citizen_Science"><img src="https://static.igem.org/mediawiki/2014/5/5d/Citizensciencev2.png"></a></div>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/MOOC"><img src="https://static.igem.org/mediawiki/2014/f/f7/PBiconemooc.png"></a></td><td></td>
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<div class=case3><a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter"><img src="https://static.igem.org/mediawiki/2014/e/e7/Newsletterv2.png"></a></div>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Citizen_Science"><img src="https://static.igem.org/mediawiki/2014/b/bb/PBiconesscici.png"></a></td><td></td>
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</div>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/The_Smell_Game"><img src="https://static.igem.org/mediawiki/2014/e/e7/PBiconesmellgame.png"></a></td><td></td>
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<div id=line2>
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                                <td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Art"><img src="https://static.igem.org/mediawiki/2014/3/39/PBiconedesign.png"></a></td>
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<div class=case4><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook"><img src="https://static.igem.org/mediawiki/2014/b/bd/Notebookv2.png"></a></div>
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<div class=case5><a href="https://2014.igem.org/Team:Paris_Bettencourt/Facts"><img src="https://static.igem.org/mediawiki/2014/0/07/Factsv2.png"></a></div>
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<div class=case6><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team"><img src="https://static.igem.org/mediawiki/2014/6/6f/Teamv2.png"></a></div>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter"><img src="https://static.igem.org/mediawiki/2014/7/75/PBiconnews.png"></a></td><td></td>
 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Minder"><img src="https://static.igem.org/mediawiki/2014/c/c6/PBiconminder.png"></a></td><td></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Facts_Smell"><img src="https://static.igem.org/mediawiki/2014/4/4d/PBiconfacts.png"></a></td><td></td>
 +
                              <td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Art_Gallery"><img src="https://static.igem.org/mediawiki/2014/d/d4/PBiconartgal.png"></a></td></tr></table>
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Latest revision as of 18:43, 5 December 2014


Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few.

The iGEM Paris Bettencourt 2014 project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.

Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell just like themselves.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
Copyright (c) 2014 igem.org. All rights reserved.

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