Team:Evry
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+ | <h1>Welcome to the <b><span style="color:#bb8900">Sponge Patrol</span></b> Home Page</h1> | ||
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- | < | + | <p align="center"><b> The wiki is under heavy construction. <b></p> |
- | < | + | <p align="center"><b>The aim of our team this year is to design and realize a <em>filtration system</em> allowing to <em>detect and degrade polluants present in water</em>. </b></p> |
- | < | + | Cette année, l’objectif de notre équipe est de développer un système de |
+ | filtration qui permettrait de détecter et de dégrader des polluants présents | ||
+ | dans l’eau. | ||
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- | < | + | <h3 align="center">The Team</h3> |
+ | <img src="https://static.igem.org/mediawiki/2014/9/9c/Evry2014Team.jpeg" alt="team photo" width="100%"/> | ||
+ | </div> | ||
+ | </div> | ||
+ | <h3 align="center">Abstract</h3> | ||
- | < | + | <p>Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Vestibulum tortor quam, feugiat vitae, ultricies eget, tempor sit amet, ante. Donec eu libero sit amet quam egestas semper. Aenean ultricies mi vitae est. Mauris placerat eleifend leo. Quisque sit amet est et sapien ullamcorper pharetra. Vestibulum erat wisi, condimentum sed, commodo vitae, ornare sit amet, wisi. Aenean fermentum, elit eget tincidunt condimentum, eros ipsum rutrum orci, sagittis tempus lacus enim ac dui. Donec non enim in turpis pulvinar facilisis. Ut felis. Praesent dapibus, neque id cursus faucibus, tortor neque egestas augue, eu vulputate magna eros eu erat. Aliquam erat volutpat. Nam dui mi, tincidunt quis, accumsan porttitor, facilisis luctus, metus</p> |
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+ | Our project focuses on developing a novel treatment for <a href="https://2013.igem.org/Team:Evry/Project_diseases"><em>hematological disorders</em></a> caused by an <a href="https://2013.igem.org/Team:Evry/Project_metabolism"><em>iron overload</em></a>, such as hemochromatosis and thalassemia. These autosomal recessive disorders have symptoms including cirrhosis, arthritis, and heart failure, which result from overabsorption of iron from the duodenum. Although these are among the most common heritable diseases, treatment options are limited. Even today patients are mostly treated by frequent bloodletting, which <a href="https://2013.igem.org/Team:Evry/HumanPractice/Patients_perceptions"><em>many people cannot support</em></a>. The aim of our project is to combat these diseases at the source by developing a therapy that prevents the intestinal absorption of iron. | ||
+ | </p> | ||
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- | <a href="https://igem.org/Team | + | We engineer the <i>Escherichia coli</i> <a href="https://2013.igem.org/Team:Evry/Project_FUR"><em>Ferric Uptake Regulation</em></a> (FUR) system using a <a href="https://2013.igem.org/Team:Evry/Inverter"><em>genetic inverter</em></a> so that they produce siderophores (<a href="https://2013.igem.org/Team:Evry/Chelator"><em>iron chelators</em></a>) in response of high concentrations of iron. These engineered bacteria are delivered to the patient's intestine by encapsulating them in an ingestible polymer (<a href="https://2013.igem.org/Team:Evry/Pill_design"><em>capsule</em></a>) that specifically degrades in the duodenum. Once released into the intestine, the bacteria respond to ambient iron by secreting elevated levels of siderophores, thereby chelating the iron to prevent its absorption by the patient. |
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- | < | + | <h3 align="center">Overview of the project and the achievements</h3> |
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+ | <img align="center" id="ModMap" src="https://static.igem.org/mediawiki/2013/4/4d/IGEM_Timeline.png" width="850" class="mapper" usemap="#overview_link" style="z-index:500;"/> | ||
+ | <map name="overview_link"> | ||
+ | <area shape="rect" coords="60,61,210,82" target="Project FUR" href="https://2013.igem.org/Team:Evry/Project_FUR" /> | ||
+ | <area shape="rect" coords="60,82,210,103" target="Results" href="https://2013.igem.org/Team:Evry/Results" /> | ||
+ | <area shape="rect" coords="60,103,210,124" target="Results" href="https://2013.igem.org/Team:Evry/Results#AceB_GFP" /> | ||
+ | <area shape="rect" coords="228,63,378,82" target="Inverter" href="https://2013.igem.org/Team:Evry/Inverter" /> | ||
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+ | <area shape="rect" coords="228,82,378,101" target="Results" href="https://2013.igem.org/Team:Evry/Results#Inverter" /> | ||
+ | <area shape="rect" coords="399,63,556,80" target="Chelator" href="https://2013.igem.org/Team:Evry/Chelator" /> | ||
+ | <area shape="rect" coords="399,103,556,120" target="Results" href="https://2013.igem.org/Team:Evry/Chelator#caracterization_siderophore" /> | ||
+ | <area shape="rect" coords="399,83,556,100" target="Chelator" href="https://2013.igem.org/Team:Evry/Chelator#Second_design" /> | ||
+ | <area shape="rect" coords="633,76,841,94" target="Expert consultation" href="https://2013.igem.org/Team:Evry/HumanPractice/Expert_consultation" /> | ||
+ | <area shape="rect" coords="633,156,841,174" target="Philosophy" href="https://2013.igem.org/Team:Evry/Philosophy" /> | ||
+ | <area shape="rect" coords="633,136,841,154" target="Safety" href="https://2013.igem.org/Team:Evry/Safety" /> | ||
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+ | <area shape="rect" coords="633,96,841,114" target="Patients perceptions" href="https://2013.igem.org/Team:Evry/HumanPractice/Patients_perceptions" /> | ||
+ | <!-- | ||
+ | <area shape="rect" coords="443,457,659,474" href="https://2013.igem.org/Team:Evry/Model1#Results" /> | ||
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+ | --> | ||
+ | <area shape="rect" coords="118,276,283,294" target="Norms from the European Pharmacopeoa" href="https://2013.igem.org/Team:Evry/Pill_design#norm" /> | ||
+ | <area shape="rect" coords="118,296,283,314" target="Overcoming the acidity" href="https://2013.igem.org/Team:Evry/Pill_design#acidity" /> | ||
+ | <area shape="rect" coords="303,276,497,294" target="Dissolution in the jejunum" href="https://2013.igem.org/Team:Evry/Pill_design#jejunum"/> | ||
+ | <area shape="rect" coords="303,294,497,312" target="Survival after the process" href="https://2013.igem.org/Team:Evry/Pill_design#conclusion" /> | ||
- | < | + | <area shape="rect" coords="631,175,794,195" href="https://2013.igem.org/Team:Evry/Economy" /> |
- | + | <area shape="rect" coords="159,402,448,423" href="https://2013.igem.org/Team:Evry/Modelmeta1" /> | |
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- | < | + | <area shape="rect" coords="462,464,595,484" href="https://2013.igem.org/Team:Evry/Modeltr1" /> |
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+ | <area shape="rect" coords="464,524,673,558" href="https://2013.igem.org/Team:Evry/Modeltr2" /> | ||
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+ | alert("Our team is proud to announce that we were awarded a gold medal and the Best Human Practice price at the european jamboree! We are going to Boston.\n\nUnfortunately, we are missing a few thousands of euros to be capable of finishing the competition. If you are a company and would like to sponsor our team, please contact us at igemevry@gmail.com.") | ||
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Revision as of 10:46, 29 July 2014
Welcome to the Sponge Patrol Home Page
The wiki is under heavy construction.
The aim of our team this year is to design and realize a filtration system allowing to detect and degrade polluants present in water.
Cette année, l’objectif de notre équipe est de développer un système de filtration qui permettrait de détecter et de dégrader des polluants présents dans l’eau.The Team
![team photo](https://static.igem.org/mediawiki/2014/9/9c/Evry2014Team.jpeg)
Abstract
Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Vestibulum tortor quam, feugiat vitae, ultricies eget, tempor sit amet, ante. Donec eu libero sit amet quam egestas semper. Aenean ultricies mi vitae est. Mauris placerat eleifend leo. Quisque sit amet est et sapien ullamcorper pharetra. Vestibulum erat wisi, condimentum sed, commodo vitae, ornare sit amet, wisi. Aenean fermentum, elit eget tincidunt condimentum, eros ipsum rutrum orci, sagittis tempus lacus enim ac dui. Donec non enim in turpis pulvinar facilisis. Ut felis. Praesent dapibus, neque id cursus faucibus, tortor neque egestas augue, eu vulputate magna eros eu erat. Aliquam erat volutpat. Nam dui mi, tincidunt quis, accumsan porttitor, facilisis luctus, metus