Team:UT-Dallas

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<section id="titlechart"></html>{{Header_menu}}<html><div id="project_desc"><br><h2>PROJECT</H2><p>
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Treating infectious diseases of the gastrointestinal (GI) tract with antibiotics disrupts a patient's gut microbiota and can increase the prevalence of antibiotic resistant strains. The increasing population of multi-drug resistant bacterial strains, both within and outside of health centers, is a growing health concern that is becoming progressively difficult to treat. Additionally, it is a well-recognized fact within the global health community that traditional antibiotics do not represent a sustainable method of treatment for bacterial infections. There is a clear drive towards minimally invasive, prophylactic therapies for such ailments, but is a demand that so far, has not been adequately met. Our project will aim at replacing broad and narrow spectrum antibiotics with “precision therapies” that have etiology targeting capacity at the species level as well as contain minimal cross-talk among healthy tissues, organs, and symbiotic organisms.
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<h2>UT Dallas iGEM</h2>
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<div id="project_desc"><br><br><h2>PROJECT</H2><br>
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Treating infectious diseases of the gastrointestinal (GI) tract with antibiotics disrupts a patient's gut microbiota and can increase the prevalence of antibiotic resistant strains. The increasing population of multi-drug resistant bacterial strains, both within and outside of health centers, is a growing health concern that is becoming progressively difficult to treat. Additionally, it is a well-recognized fact within the global health community that traditional antibiotics do not represent a sustainable method of treatment for bacterial infections. There is a clear drive towards minimally invasive, prophylactic therapies for such ailments, but is a demand that so far, has not been adequately met. Our project will aim at replacing broad and narrow spectrum antibiotics with “precision therapies” that have etiology targeting capacity at the species level as well as contain minimal cross-talk among healthy tissues, organs, and symbiotic organisms.
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We envision a new paradigm for treating infections of the human gastrointestinal tract through exploitation of engineered probiotics that produce anti-microbials with high specificity for pathogens. The anti-microbials we are exploring do not utilize a one-fit all therapy mold, but target unique features specific to organisms at the genetic level. Towards this aim, we have utilized a general-purpose system that will be delivered to pathogenic bacteria from an engineered bacterial species found in the GI tract (Escherichia coli), which will cleave pathogenic genes with single nucleotide resolution. To achieve specific genome targeting, we will utilize the CRISPR/Cas9 system with gRNA engineered to recognize genes from infectious bacteria that contribute to pathogenicity in humans. Our CRISPR/Cas9 system will be delivered from the engineered E. coli to infectious bacteria using bacterial specific phages, minimizing any side-effects to native microbiota and human-host cells. As a proof-of-principle for our engineered probiotic, we are starting by targeting Vibrio cholerae, however we hope to expand the system to other pathogens of the GI tract.
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<p>Content 1</p>
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<br><h2>THE TEAM</H2><br><p>
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  <img src="https://static.igem.org/mediawiki/2014/1/13/Tyler-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Tyler</h2>Hey there! My name is Tyler. I graduated in 2013 as a biochemistry major at the University of Texas at Dallas. <p>I participated in iGEM in 2011 as a student and this year served as the UT Dallas iGEM team advisor.
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I think iGEM provides an excellent opportunity to get students involved in biomedical research.
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In the future, I hope to utilize synthetic biology to tackle problems in the medical field.">
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  <img src="https://static.igem.org/mediawiki/2014/3/34/Sam-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Samantha</h2>Hello! My name is Samantha and I recently graduated from UTD with a BSc in Biology. I am interested in synthetic biology because it offers very unique and dynamic solutions to complicated problems. I joined iGEM because it's an excellent platform for creative collaboration among young scientists. When I am not in the lab... it's probably because I just left to get more coffee and am on my way back to the lab.">
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  <img src="https://static.igem.org/mediawiki/2014/5/56/Megan-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Megan Zerez</h2>Megan Zerez is a molecular biology sophomore (or junior, she’s not entirely sure) at UT Dallas. She enjoys getting used books in the mail, building things and being a food snob. She has a pet ukulele and a tendency to not attend lecture. She does not do voice modulation and likes to talk about all of these things maybe a bit too loudly, much to the chagrin of our neighbors at NSERL. In addition to wet-lab work, Megan worked on the wiki and human practices project.">
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  <img src="https://static.igem.org/mediawiki/2014/8/8b/Tra-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Tra Ngo</h2>Tra is biology major but she is still deciding between Molecular Cell Biology and Mathematics. Nevertheless, she loves both. Since she is good at math, she does the biological system modelling for our project, despite having any prior programming experience. She learned gro and MatLab just for iGEM. Aside from wet lab work, she also helps with building the wiki. Tra loves languages. She is learning Japanese, Russian, html, and css. When there is dead time in the lab you will find her occasionally engaging in conversations on the topic of Math as a language with our labs post-doc. In between reactions, if she is not utilizing time by cleaning the lab bench, Tra would do calligraphy on the white board. Tra is an iGEM late-comer but she soon became an essential part of the team.
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<br><br>The song ‘Tra's Brief Life as a Spider’ reveals her life prior to iGEM. She was briefly reincarnated as a spider, then later, as a Wild Horse on the planet of nearly, where wild horses hold the majority in the senate. She likes pudding, but only without raisins.
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<br><br>When not doing iGEM wet lab and dry lab work, Tra enjoys swing dancing, sacrificing bishops (in chess club), setting ants on fire with isopropanol, and slashing people with sabre (in fencing club). She occasionally bring borscht, mooncakes, and cashew butter to the lab.
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<br><br>Tra is at the same time engaging in a math research. She is looking to further the application of math in the study of biology.">
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  <img src="https://static.igem.org/mediawiki/2014/8/80/Rishika-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Rishika</h2>I’m a sophomore majoring in Molecular Biology. I’m an avid Netflixer and love ice cream, napping, windy days, Chipotle, and going to airports (in that order). In lab I can most likely be found in front of the centrifuges at the Miniprep station or in front of the whiteboard admiring the lovely tables and diagrams. iGEM has been a great opportunity where I learned tons about everything ranging from the CRISPR-Cas9 system to ‘crunchy bread,’ and had a lot of fun while doing so.">
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  <img src="https://static.igem.org/mediawiki/2014/e/e7/Kortne-profile-image.png" height="400px" width="400px" class="tooltip" title="<h2 class='info_h2'>Kortne</h2>Hello, my name is Kortne Banks and I am a senior studying biology at The University of Texas at Dallas. When I am not busy studying for exams I love to spend my free time tutoring children and writing. I am currently writing a children’s book that aims towards inspiring children to pursue their dreams. A goal of mine is to one day start a nonprofit organization that helps children excel in stem careers. What prompted me to participate in Igem was my amazement on how much power the students have over choosing a project for the jamboree competition. I initially had zero bacterial cloning experience and now I am a cloning machine. I also learned a few web design techniques using html for our team wiki page. Igem has been an amazing opportunity for me and there is no doubt that this summer has been an unforgettable experience.  ">
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Latest revision as of 22:25, 29 December 2014


PROJECT

Treating infectious diseases of the gastrointestinal (GI) tract with antibiotics disrupts a patient's gut microbiota and can increase the prevalence of antibiotic resistant strains. The increasing population of multi-drug resistant bacterial strains, both within and outside of health centers, is a growing health concern that is becoming progressively difficult to treat. Additionally, it is a well-recognized fact within the global health community that traditional antibiotics do not represent a sustainable method of treatment for bacterial infections. There is a clear drive towards minimally invasive, prophylactic therapies for such ailments, but is a demand that so far, has not been adequately met. Our project will aim at replacing broad and narrow spectrum antibiotics with “precision therapies” that have etiology targeting capacity at the species level as well as contain minimal cross-talk among healthy tissues, organs, and symbiotic organisms.




THE TEAM



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