Template:Team:Marburg/Template:StartLines

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<a href="https://2014.igem.org/Team:Marburg:Project:Silver" aria-haspopup="true">
<img src="https://static.igem.org/mediawiki/2014/b/b5/MR_start_silverSURF.png" alt="SilverSURF">
<img src="https://static.igem.org/mediawiki/2014/b/b5/MR_start_silverSURF.png" alt="SilverSURF">
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<b>SilverSURF</b>
<b>SilverSURF</b>
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<span>Environmental pollution with harmful quantities of heavy metal ions has become an urgent problem in these times.  
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<span>Environmental pollution with harmful quantities of heavy metal ions has become an urgent problem.<br />SilverSURF makes use of the flagellar filament that represents one of the largest scaffolds in nature, and combines it with the unique potential of high-affinity metal-ion-binding domains.
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SilverSURF makes use of the flagellar filament that represents one of the largest scaffolds in nature, and combines it  
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with the unique potential of high-affinity metal-binding domains. Specifically, we rationally designed synthetic flagellar
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filaments able to bind huge quantities of the metal ion silver and copper. </span>
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<a href="https://2014.igem.org/Team:Marburg:Project:Tumor" aria-haspopup="true">
<img src="https://static.igem.org/mediawiki/2014/4/41/MR_start_cancerSURF.png" alt="CancerSURF">
<img src="https://static.igem.org/mediawiki/2014/4/41/MR_start_cancerSURF.png" alt="CancerSURF">
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<b>CancerSURF</b>
<b>CancerSURF</b>
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<span>Lung cancer is one of the most malignant cancers with poor prognosis. Next to the common therapies like surgery,
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<span>Lung cancer is one of the most malignant cancers with poor prognosis.<br />CancerSURF combines the scaffold of a tetrameric Streptavidin to increase the specificity of a DARPin to detect a prominent tumor marker. This system can find several applications in medical treatment or as a diagnostic tool.
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radiation therapy and chemotherapy, antibody therapy is more specific. CancerSURF combines the scaffold of a tetrameric  
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Streptavidin to increase the specificity of a DARPin to detect a prominent tumor marker of lung cancer cells, called EpCAM.  
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This system can find several approaches in medical treatment, for example serving as an inhaled alternative to chemotherapy
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or as a diagnostic tool via surgery, indicating remaining tumor cells.  
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<a href="https://2014.igem.org/Team:Marburg:Project:NRPS" aria-haspopup="true">
<img src="https://static.igem.org/mediawiki/2014/8/86/MR_start_riboSURF.png" alt="RiboSURF">
<img src="https://static.igem.org/mediawiki/2014/8/86/MR_start_riboSURF.png" alt="RiboSURF">
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<b>RiboSURF</b>
<b>RiboSURF</b>
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<span>Ribosomes synthesize proteins from amino acids using mRNA as blueprint and tRNAs delivering amino acids. However,
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<span>Ribosomes are limited to 20 L-amino acids while non-ribosomal peptide synthetases (NRPSs) can use a large number of natural and non-proteinogenic amino acids. RiboSURF aims at combining the huge repertoire of NRPSs with ribosomal protein synthesis to extend the synthetic scope of the ribosome.
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the natural ability of ribosomes is limited to 20 L-amino acids. Non-ribosomal peptide synthetases (NRPSs) synthesize
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only small peptides, however, from a large number of natural and non-proteinogenic amino acids. RiboSURF aims at  
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combining the huge repertoire of NRPSs with ribosomal protein synthesis to extend the synthetic scope of the ribosome.
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Specifically; we designed and probed the potential of synthetic catalysts that allow the aminoacetylation of tRNAs
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with non-proteinogenic amino acids.  
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<a href="https://2014.igem.org/Team:Marburg:Safety" aria-haspopup="true">
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<img src="https://static.igem.org/mediawiki/2014/f/fe/Mr_home_test.png" alt="SURFkiller">
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<img src="https://static.igem.org/mediawiki/2014/c/cb/MR_SURFkiller.png" alt="SURFkiller">
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<b>SURFkiller</b>
<b>SURFkiller</b>
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<span>The work with genetically modified organisms (GMOs) harbours the risk of their release to the nature. After release,  
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<span>The work with genetically modified organisms (GMOs) harbours the risk of their release into nature. Therefore, it is necessary to make their survival in nature impossible.<br />We developed a security system for <em>Bacillus subtilis</em> based on one of the cells essential compartment the ribosome.  
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serious consequences such as gene exchange with unmodified organism or ecosystem imbalance cannot be excluded. It is  
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necessary to keep GMOs isolated from the environment or to make their survival in nature impossible. For this purpose,
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we decided to develop a security system for Bacillus subtilis. This system is based on one of the cells most important
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compartment- the ribosome. Ribosomes are essential as they are responsible for the protein synthesis and a loss of them
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leads to a halt of protein biosynthesis resulting in a rapid cell death.  
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Latest revision as of 12:19, 23 November 2014

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