Team:Calgary

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<img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot">
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<h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> DETECTOR</h2>
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<h2 class="HomeBsDetectorH2"><i>B.s.</i> Detector</h2>
<p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p>
<p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p>
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<section class="Content Text Color-Light" id="HomeMisdiagnosis">
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<h2 class="HomeMisdiagnosisH2">MALARIA MISDIAGNOSIS</h2>
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<h2 class="HomeMisdiagnosisH2">Misdiagnosis of Infectious Diseases</h2>
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<p class="HomeMisdiagnosisP">Infectious diseases including dengue fever, typhoid fever, and meningitis are symptomatically similar to malaria, and thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. The lack of reliable rapid diagnostic tests to diagnose diseases, such as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these diseases contribute significantly to the problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite a lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients, in addition to a loss of faith in established health services. Misdiagnosis can also result in increased economic burdens and anti-malarial drug resistance. In Sudan, the 2000 annual cost of both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria.</p>
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<p class="HomeMisdiagnosisP">Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are <b>often misdiagnosed</b> in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a <b>novel, genome-based, rapid point-of-care synthetic biological device</b> to simultaneously diagnose multiple infectious diseases.</p>
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<section class="Content Text Color-Orange" id="HomeCaseStudy">
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<h2 class="HomeCaseStudyH2">CASE STUDY</h2>
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<h2 class="HomeCaseStudyH2">Global Impact</h2>
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<p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p>
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<p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p>
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<p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p>
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<p class="HomeCaseStudyP">Patients who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs despite their diagnosis. The over-prescription of antimalarials fosters an environment for the emergence of <b>drug resistance</b> and worsens the patient's condition.</p>
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<h2 class="HomeOurDeviceH2">OUR DEVICE, OUR IDEA</h2>
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<p class="HomeOurDeviceP">iGEM Calgary 2014 team is using synthetic biology to develop a <span class="HomeBigText">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</span> device to simultaneously diagnose multiple infectious diseases.</p>
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<h2 class="HomeOurDeviceH2">Our Device, Our Idea</h2>
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<p class="HomeOurDeviceP">We are engineering <b><i>Bacillus subtilis</i></b> to generate chromophoric reporter proteins in response to pathogenic genetic markers.</p>
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<h2 class="HomeComponentsH2">COMPONENTS OF OUR SYSTEM</h2>
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<h2 class="HomeComponentsH2">Components of Our System</h2>
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<p class="HomeComponentsP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases is of particular concern.</p>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/BsDetector"><img src="https://static.igem.org/mediawiki/2014/0/00/2014UCalgaryButtonDetector.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/BsDetector/GeneticCircuit"><img src="https://static.igem.org/mediawiki/2014/c/c5/2014UCalgaryButtonGeneticCircuit.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/Collaboration"><img src="https://static.igem.org/mediawiki/2014/7/7e/2014UCalgaryButtonCollaboration.png"/></a></div>
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<div class="button"><a href="https://2014.igem.org/Team:Calgary/PoliciesAndPractices"><img src="https://static.igem.org/mediawiki/2014/0/0f/2014UCalgaryButtonPolicy.png"/></a></div>
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Latest revision as of 03:55, 18 October 2014

B.s. Detector

We are developing a novel, genome-based, point-of-care synthetic biological device to simultaneously diagnose multiple infectious diseases that are prevalent worldwide.

Misdiagnosis of Infectious Diseases

Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a novel, genome-based, rapid point-of-care synthetic biological device to simultaneously diagnose multiple infectious diseases.

Global Impact

Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases will double over the next 20 years. From the public-health perspective, misdiagnosis of malaria results in excessive reporting of malaria cases, while those that mimic malaria are under-reported.

Patients who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs despite their diagnosis. The over-prescription of antimalarials fosters an environment for the emergence of drug resistance and worsens the patient's condition.

Our Device, Our Idea

We are engineering Bacillus subtilis to generate chromophoric reporter proteins in response to pathogenic genetic markers.

Components of Our System

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