Team:MIT

From 2014.igem.org

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<tr><td><h3 style="font-size:20px; color:teal" align=center><b>IMPROVING THE DIAGNOSIS AND TREATMENT OF</u></h3></td></tr>
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<tr><td><h3 style="font-size:50px; color:teal" align=center><b>ALZHEIMER'S DISEASE</b></h3></td></tr>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/6/6b/MIT_homepage_dying_neuron.png"></td>
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<h1 style="color:#E7E7E7">MIT iGEM 2014</h1>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e4/MIT_homepage_sixth.png"></td>
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<p style="color:#E7E7E7">Our wiki is currently under construction, so please bear with us as we continue to update it over the coming weeks.
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:MIT&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<td width=33.3%><p style="font-size:12px; color:teal" align=top><b> NEURODEGENERATIVE <br>DISEASE </b></p></td>
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<td width=33.3%><p style="font-size:12px; color:teal"><b> 6th LEADING CAUSE OF<br> DEATH IN THE U.S.</b></p></td>
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<td width=33.3%><p style="font-size:12px; color:teal"><b> CURRENT DIAGNOSTICS AND<br> THERAPEUTICS ARE INEFFECTIVE</b></p></td>
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<tr><td><br><p style="font-size:15px" align=left><b>Alzheimer's disease is the sixth leading cause of death</b> in the United States, affecting more than 5 million Americans and resulting in the deaths of 500,000 people every year (Alzheimer's Association).  Though one in three seniors dies with this disease (Alzheimer's Association), it currently has no cure, and, according to the clinicians that we interviewed, existing diagnosis methods are unreliable.  <b>MIT iGEM 2014 is working to change this situation.</b> We set out to devise a way to diagnose Alzheimer's disease using biological rather than psychological tests and to invent a treatment mechanism that would capitalize on recent findings about the molecular pathology of the disease.  Using the principles of synthetic biology, we designed a system that <b>detects molecular biomarkers</b> for Alzheimer's disease and <b>alters the levels of key enzymes</b> in response.  Our dynamic system combats Alzheimer's disease only when the disease is detected, providing a specific, state-sensitive treatment. In the future, an approach like ours could provide a solution for patients suffering from the debilitating effects of Alzheimer's disease and improve the lives of their caretakers and family.
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<tr><td colspan=3><h3 style="font-size:25px; color:teal">DETECTION</h3></td>
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<tr>outline for this page
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<br />background and motivation
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<br />--Alzheimers is bad
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<br />--we have synth bio tools and such
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<br />-What our system is (intro)
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<br />--diagram of system (sensing and treatment flow chart)
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<br />-Rough progress
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<br />--experimental outcome (eg we think its on the membrane)
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<br />--link to results page(s)
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<br />-future
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<br />--Treatment goal
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<br />--reusable and separable parts
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<br />---If our whole system together doesn't get to market (I doubt it will), we will have parts that will be useful to other researchers
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<br />---BCR and miRNA both are very universal (but more on each parts page)
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<br />--Perhaps mention microglia as alternative treatment path
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<br />--link to delivery page
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<tr>bellow is default stuff they started us out with, will be same on other pages</tr>
 
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/Protein_sensor"><img src="https://static.igem.org/mediawiki/2014/e/e9/MIT_Native_receptor_homepage.png"><br><p style="font-size:12px; color:black"><b>NATIVE β-AMYLOID RECEPTOR</b></p></a></td>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/BCR"><img src="https://static.igem.org/mediawiki/2014/f/f8/MIT_bcr_homepage.png"><br><p style="font-size:12px; color:black"><b>ENGINEERED B-CELL RECEPTOR</b></p></a></td>
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<td width=33.3%><a href="https://2014.igem.org/Team:MIT/miRNA"><img src="https://static.igem.org/mediawiki/2014/8/88/MIT_mirna_homepage.png"><br><p style="font-size:12px; color:black"><b>miRNA DETECTION</b></p></a></td>
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<li><a href="https://2014.igem.org/Team:MIT">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:MIT/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=MIT">Official Team Profile</a> </li>
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<tr><td><h3 style="font-size:23.5px; color:teal">TREATMENT</h3></td>
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<li><a href="https://2014.igem.org/Team:MIT/Project">Project</a> </li>
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<td><h3 style="font-size:23.5px; color:teal">DELIVERY</h3></td>
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<li><a href="https://2014.igem.org/Team:MIT/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:MIT/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:MIT/Notebook">Notebook</a> </li>
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<li><a href="https://2014.igem.org/Team:MIT/Safety">Safety</a> </li>
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<li><a href="https://2014.igem.org/Team:MIT/Attributions">Attributions</a> </li>
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<p>There are a few wiki requirements teams must follow:</p>
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<li>All pages, images and files must be hosted on the <a href ="https://2014.igem.org/Special:Upload"> 2014.igem.org server</a>. </li>
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<li>All pages must be created under the team’s name space.</li>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<td width=50%><a href="https://2014.igem.org/Team:MIT/Treatment"><img src="https://static.igem.org/mediawiki/2014/1/19/MIT_treatment_homepage.png"></a></td>
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<p>We are currently working on providing teams with some easy to use design templates.
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<td width=50%><a href="https://2014.igem.org/Team:MIT/Delivery"><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"></a></td>
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<tr><td><a href="https://2014.igem.org/Team:MIT/Treatment"><p style="font-size:12px; color:black"><b>REGULATING β-AMYLOID PRODUCTION<br>AND DEGRADATION</b></p></a></td>
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<td><a href="https://2014.igem.org/Team:MIT/Delivery"><p style="font-size:12px; color:black"><b>DELIVERING THE CIRCUIT</b></p></a></td>
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<tr><td><p style="font-size:12px" align=center><i>Attributions: Kathryn Brink, Alexa Garcia, Shinjini Saha<br>Kathryn Brink (Content), Alexa Garcia (Content), Shinjini Saha (Illustrations)<br> Special mention: Shinjini Saha (Illustrations for entire website)</i></p></td></tr>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 03:54, 18 October 2014

 


Image Map
Home Our Project Lab Work Outreach About Us Medals



IMPROVING THE DIAGNOSIS AND TREATMENT OF

ALZHEIMER'S DISEASE


NEURODEGENERATIVE
DISEASE

6th LEADING CAUSE OF
DEATH IN THE U.S.

CURRENT DIAGNOSTICS AND
THERAPEUTICS ARE INEFFECTIVE



Alzheimer's disease is the sixth leading cause of death in the United States, affecting more than 5 million Americans and resulting in the deaths of 500,000 people every year (Alzheimer's Association). Though one in three seniors dies with this disease (Alzheimer's Association), it currently has no cure, and, according to the clinicians that we interviewed, existing diagnosis methods are unreliable. MIT iGEM 2014 is working to change this situation. We set out to devise a way to diagnose Alzheimer's disease using biological rather than psychological tests and to invent a treatment mechanism that would capitalize on recent findings about the molecular pathology of the disease. Using the principles of synthetic biology, we designed a system that detects molecular biomarkers for Alzheimer's disease and alters the levels of key enzymes in response. Our dynamic system combats Alzheimer's disease only when the disease is detected, providing a specific, state-sensitive treatment. In the future, an approach like ours could provide a solution for patients suffering from the debilitating effects of Alzheimer's disease and improve the lives of their caretakers and family.





DETECTION

NATIVE β-AMYLOID RECEPTOR

ENGINEERED B-CELL RECEPTOR

miRNA DETECTION


TREATMENT

DELIVERY

REGULATING β-AMYLOID PRODUCTION
AND DEGRADATION

DELIVERING THE CIRCUIT

Attributions: Kathryn Brink, Alexa Garcia, Shinjini Saha
Kathryn Brink (Content), Alexa Garcia (Content), Shinjini Saha (Illustrations)
Special mention: Shinjini Saha (Illustrations for entire website)

Retrieved from "http://2014.igem.org/Team:MIT"