Team:Tufts/future

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This October, Tufts Synthetic Biology hosted a conference, The Future of Phage and Synthetic Biology, which brought together experts from academia, industry, and regulation to discuss and present on emerging research concerning the applications of phage - specifically bacteriophage therapy.
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The conference incorporated two main events. The first was a discussion between experts, held
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under Chatham House rules, to discuss and advance a pre-written framework for bacteriophage
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applications and associated safety and regulatory considerations. This was followed by a public
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forum to present and discuss the results and implications with a more general audience before
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shifting to guided and informal discussion.
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          A long, noncoding massively expressed regulatory RNA (merRNA) discovered in Bdellovibrio bacteriovorus is present in high levels during its dormant phase. The merRNA is believed to sequester cyclic-di-GMP, much like a sponge. Since cyclic-di-GMP is a second messenger for various cellular functions, including motility and biofilm formation, the Tufts iGEM team introduced this merRNA sequence into E. coli. Constitutive expression of this merRNA transcript was shown to increase biofilm formation. This property can be useful in microbe-based approaches to environmental remediation. Earlier designs for phage delivery of the merRNA to disrupt biofilms inspired an investigation into the policy surrounding engineered bacteriophage. Tufts iGEM will be convening a panel of experts from various disciplines to put forth recommendations for the responsible use of phage in therapeutic and industrial applications. A proposal will be drafted for a silk bandage containing a phage cocktail which can prevent and treat infection by antibiotic-resistant bacteria.
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Latest revision as of 03:46, 18 October 2014

Tufts University





This October, Tufts Synthetic Biology hosted a conference, The Future of Phage and Synthetic Biology, which brought together experts from academia, industry, and regulation to discuss and present on emerging research concerning the applications of phage - specifically bacteriophage therapy.

The conference incorporated two main events. The first was a discussion between experts, held under Chatham House rules, to discuss and advance a pre-written framework for bacteriophage applications and associated safety and regulatory considerations. This was followed by a public forum to present and discuss the results and implications with a more general audience before shifting to guided and informal discussion.




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