Team:York

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<h2>Welcome to the Univeristy of York entry for iGEM 2014</h2>
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<p>Our project EcoCADMUS ( E. coli CAdmium DecontaMination Universal System)aims to target the global issue of wastewaters from industry and mineral processing being contaminated by metals and sulfates. We have focused our project on the removal of sulfates and cadnium, one of the most commonly encountered toxic heavy metals in contaminated water which is known to cause severe damage to aquatic biodiversity and to humans. The University of York iGEM team has developed a new approach to remove cadmium and sulfates from wastewater using genetically engineered Escherichia coli. Our circuit is activated by a cadmium inducible promoter and is divided into two interconnected mechanisms:<ol><li>increasing sulphate uptake and its targeting into cysteine production by engineering the cysteine biosynthesis pathway; <li> increasing cadmium uptake and targeting of the free-cysteine into metal binding proteins (phytochelatins) for metal chelation/stabilization inside and outside cell.<p/>
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<p style="font-size:150%">Our project <i>EcoCADMUS</i> (<i>E. Coli</i> CAdmium DecontaMination Universal System)  
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aims to provide a safe and effective way to remove Cadmium and Sulfate from wastewater.</p>
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<h2>The Solution</h2>
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<p style="font-size:150%">Our project is a biological approach to solving an environmental problem; the removal of cadmium and sulfate from waste water. Our aim is to increase cadmium and sulfate uptake in our chassis, <i>E.coli</i>. Our system involves chelating cadmium intra-cellularly through over-expressing cysteine-rich phytochelatins. Find out more about our project here.</p><br>
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<h2>Our Achievements</h2>
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<p style="font-size:150%">We have been working hard over summer in the labs to create our constructs. Click here to find out more about the characterisation of our constructs!</p><br>
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<p style="font-size:150%">As part of our project, we wanted to introduce the public to the concept of Genetically Modified Organisms and how they have a multitude of uses. Our outreach took us to many people and places as we explored the relationship between the public and Synthetic Biology</p><br>
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<h2>The Team</h2>
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<p style="font-size:150%">Our team is comprised of 19 undergraduates from the University of York. Find out more about the team and the people who supported us throughout this year.</p><br>
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<h2>Hello! We're from the
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<p><b>Our project <i>EcoCADMUS</i> (E. Coli CAdmium DecontaMination Universal System)
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aims to provide a safe and effective way to remove Cadmium and Sulfate from wastewater.</p>
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                <a href="https://2014.igem.org/Team:York/Project"<b>>
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            <div class="panel-heading"><h3>Our Team</h3></div>
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            <p>Come and meet our lovely team!<br>We've been working hard (mostly!) on our project all over Summer.</p>
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                <img class="img-responsive" src="https://static.igem.org/mediawiki/2014/a/ae/York_Constructs.jpg">
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                <p>To find our more about our final construct we have designed.</p>
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            <p>We have been busy communicating Synthetic Biology and contemplating the sustainability and ethics of our project. </p>
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                <a href="https://2014.igem.org/Team:York/SocialImpacts">
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Latest revision as of 02:47, 18 October 2014

Team York 2014



Hello! We're from the

Our project EcoCADMUS (E. Coli CAdmium DecontaMination Universal System) aims to provide a safe and effective way to remove Cadmium and Sulfate from wastewater.

>


Our Team

Come and meet our lovely team!
We've been working hard (mostly!) on our project all over Summer.

Our final Construct

To find our more about our final construct we have designed.

Social Outreach

We have been busy communicating Synthetic Biology and contemplating the sustainability and ethics of our project.

Retrieved from "http://2014.igem.org/Team:York"