Team:Warwick/Parts/Aptazyme

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             <h1> APTAZYME </h1> <br> <br>-->
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             <h1> APTAZYME </h1> <br> <br>
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<h2> Click <a href="https://2014.igem.org/Team:Warwick/Parts">here</a> to learn about our Aptazyme. </h2>
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<p> Our modelling in this project has several aims: </p>
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    <p>This is an RNA enzyme which self-
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<li>To find the amount of DPP-IV reduction reached when the system reaches equilibrium</li>
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cleaves in the presence of  
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<li>To find a way to control the level of DPP-IV reduction</li>
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<li>To find the minimum number of RdRps, replicons, etc to be initially transfected into the cell, which are required to achieve a steady state for the system</li>
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theophylline. Theophylline is not
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<li>To find out how long does it take for the system to reach equilibrium</li>
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<li>To find out the level of reduction we need to treat diabetes</li>
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endogenous to mammalian cells
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<li>To find out how stable the system is (i.e. will the system only work in very specific situations, or in lots of different systems?)
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hence acts as a selective “off-switch”
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in an instance such as, Hepatitis C
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infection or tumour formation which
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is exacerbated by lack of DPP-IV.</p> <br><br>
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<h2> Click <a href="http://parts.igem.org/Part:BBa_K1442006">here</a> to learn about our Aptazyme. </h2>
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Latest revision as of 02:13, 18 October 2014

APTAZYME



This is an RNA enzyme which self- cleaves in the presence of theophylline. Theophylline is not endogenous to mammalian cells hence acts as a selective “off-switch” in an instance such as, Hepatitis C infection or tumour formation which is exacerbated by lack of DPP-IV.



Click here to learn about our Aptazyme.

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