Team:UMayor-Chile/Project

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<marquee>  <h1> <cente>  PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR </center> </h1>              </marquee> <span style="color:#FFFFFF"> CHILE
<marquee>  <h1> <cente>  PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR </center> </h1>              </marquee> <span style="color:#FFFFFF"> CHILE
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<p>Hello world!! We are an official team for the iGEM 2014. We are working so hard on our project TroyHorse, but we're having a really good experience
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<p>THE PROJECT
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<p style="color:#yellow"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
<p style="color:#yellow"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<h3 style="color:#ffffff;">The Cystic Fibrosis (CF)</h3>
<h3 style="color:#ffffff;">The Cystic Fibrosis (CF)</h3>
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<p>It’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.</p>
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<p>70,000 people with CF worldwide, a lifespan depending of the resources (in USA the lifespan it’s about 40 years old, while in Chile the average lifespan it’s about 18 years old)</p>
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<p><a href="http://es.tinypic.com?ref=2hq4200" target="_blank"><img src="http://i57.tinypic.com/2hq4200.png" border="0" alt="Image and video hosting by TinyPic"></a></p>
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<p> It’s a disease caused by the expression of a deficient transmembrane protein called CFTR. This affects different kind of cells, mainly the epithelial cells from the airway and pancreas, causing the production of a defective mucus.
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<p>In the lungs, this defective mucus leads that several opportunistic pathogens enter to the lower airway and initiate an infection, with a consecutively progressive lung dysfunction.
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<h3 style="color:#ffffff;">Fig 1: Construct that allows E. coli to weak Pseudomonas's biofilm.</h3>
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<h3 style="color:#ffffff;">Epithelium</h3>
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<p><a href="http://es.tinypic.com?ref=2d960zk" target="_blank"><img src="http://i60.tinypic.com/2d960zk.jpg" border="0" alt="Image and video hosting by TinyPic"></a></p>
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<p><a href="http://es.tinypic.com?ref=ih095g" target="_blank"><img src="http://i59.tinypic.com/ih095g.png" border="0" alt="Image and video hosting by TinyPic"></a></p>
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<p>One of the main pathogens found in an infection of the lungs are the Pseudomonas aeruginosa. When it colonize the airway, initiates the production of biofilm, a barrier that protect it of a lot of antimicrobial substances and gave best environment for it develop.
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<p>The actual treatments for controlling the symptoms consist in maintain controlled the pathogens, clear the airway of the sticky mucus, administrate complementary enzymes and regulate the function of the CFTR channel.
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<p>•http://redsalud.uc.cl/ucchristus/vidasaludable/glosario/F/fibrosis_quistica.act
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<p>•http://www.fibrosisquisticadelpancreas.cl/noticias/10-generales/16-ministro-de-salud-  inauguro-congreso-de-actualizacion-en-fibrosis-quistica-.html
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<p>•http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062014000300003
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http://www.cff.org/
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Revision as of 01:28, 18 October 2014


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PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR

CHILE

THE PROJECT

Click here to edit this page!

Home Team News and events Project Parts Modeling Out the lab Safety Attributions

The Cystic Fibrosis (CF)

70,000 people with CF worldwide, a lifespan depending of the resources (in USA the lifespan it’s about 40 years old, while in Chile the average lifespan it’s about 18 years old)

Image and video hosting by TinyPic

It’s a disease caused by the expression of a deficient transmembrane protein called CFTR. This affects different kind of cells, mainly the epithelial cells from the airway and pancreas, causing the production of a defective mucus.

In the lungs, this defective mucus leads that several opportunistic pathogens enter to the lower airway and initiate an infection, with a consecutively progressive lung dysfunction.

Epithelium

Image and video hosting by TinyPic

One of the main pathogens found in an infection of the lungs are the Pseudomonas aeruginosa. When it colonize the airway, initiates the production of biofilm, a barrier that protect it of a lot of antimicrobial substances and gave best environment for it develop.

The actual treatments for controlling the symptoms consist in maintain controlled the pathogens, clear the airway of the sticky mucus, administrate complementary enzymes and regulate the function of the CFTR channel.

•http://redsalud.uc.cl/ucchristus/vidasaludable/glosario/F/fibrosis_quistica.act

•http://www.fibrosisquisticadelpancreas.cl/noticias/10-generales/16-ministro-de-salud- inauguro-congreso-de-actualizacion-en-fibrosis-quistica-.html

•http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062014000300003 http://www.cff.org/