Team:Cambridge-JIC

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                        <h1>Cambridge JIC</h1>
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                        <h4>Welcome to the page for the Cambridge University team,<br />affiliated with the John Innes Centre in Norwich.</h4>
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                <h2 class="section-heading">Mösbi: A modular plant biosensor</h2>
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                    <dt>Mösbi</dt>
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                    <h2 class="section-heading">mösbi - a plant biosensor for everyone</h2>
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                    <p> Mösbi introduces a brand new chassis to iGEM. It is Marchantia polymorpha, a compact, fast-growing and primitive plant, engineered into a flexible biosensor that could respond to a user-specified input in a user-specified way. With its modulable input, processing, and output plugins linked with transcription factors and their upstream binding sites, mösbi’s functions can be mixed and matched either using traditional molecular techniques or via sexual crossing to create a tailor-made biosensor suiting anyone’s needs in the comfort of their own homes. Click <a href="Team:Cambridge-JIC/Mosbi">here</a> to find out more.</p>
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                    <p class="lead"><b>mӧsbi</b> stands for <b>m</b>archantia <b>o</b>pen-<b>s</b>ource <b>bi</b>osensor. mӧsbi encapsulates the team's vision of creating a user-friendly, open-source biosensor using the liverwort <i>Marchantia polymorpha</i>. With its sturdy genetic framework and modularity, mӧsbi represents a new step in popularising synthetic biology and making it accessible to a large audience. Click <a href="https://2014.igem.org/Team:Cambridge-JIC/Project/Overview">here</a> to find out more.</p>
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                    <dt>Marchantia </dt>
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                    <h2 class="section-heading"><i>Marchantia polymorpha</i> as a new chassis</h2>
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                    <p> Our novel, eukariotic multicellular chassis is Marchantia Polymorpha. As a liverwort it is one of the most primitive current land plants; its small size and relative genetic simplicity make it easy to work with in a number of ways. Content to grow on agar plates, Marchantia can be engineered in a standard bacterial lab with minimal extra equipment. Click <a href="Team:Cambridge-JIC/Marchantia">here</a> to find out more about the plant, and <a href="Team:Cambridge-JIC/Guide">here</a> to learn how to get started using Marchantia in your own iGEM project.</p>
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                    <p class="lead"> <i><b>Marchantia polymorpha</b></i> is our novel, eukaryotic multicellular chassis. Being a liverwort, it is one of the most primitive land plants around. Its small size and relative genetic simplicity make it easy to work with and an exciting new model organism in synthetic biology. Content to grow on agar plates, marchantia can be bioengineered in a standard lab with minimal extra equipment. Click <a href="https://2014.igem.org/Team:Cambridge-JIC/Marchantia/Background">here</a> to find out more about the plant and our work to develop the chassis; and <a href="https://2014.igem.org/Team:Cambridge-JIC/Guide">here</a> to learn how to get started using <i>Marchantia</i> in your own iGEM project.</p>
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                    <dt>Results </dt>
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                    <h2 class="section-heading">Results</h2>
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                    <p> We successfully transformed hundreds of Marchantia plants, expressed a chromoprotein in a plant for the first time, built an arduino-controlled growth chamber, introduced a new enzyme to iGEM, and characterised an old one. </p>
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                    <p class="lead">We successfully transformed hundreds of individual plants, resulting in the first expression of chromoproteins in <i>Marchantia</i>, and probably the first expression of chromoproteins in any plant. We successfully built an arduino-controlled growth chamber, characterised an enzyme new to iGEM and amended the community's knowledge of an existing registry entry. A known <i>Marchantia</i> promoter was also added to the registry, along with 27 candidate promoters from the <i>Marchantia</i>genome. They are part of a <i>Marchantia</i> starter kit part collection that also includes terminators, direction sequences, etc. Finally, we submitted an RFC with collaboration of two other iGEM teams, establishing a unified Type IIS based grammar for plant synthetic biologist: PlantSyntax. Click <a href="https://2014.igem.org/Team:Cambridge-JIC/Results/Lab">here</a> for more result details, and <a href="https://2014.igem.org/Team:Cambridge-JIC/ExecSummary">here</a> for our executive summary.</p>
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                    <h2 class="section-heading">Our team</h2>
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                    <p class="lead">We are nine Cambridge science undergraduates from various backgrounds and with all kinds of fascinating and curious interests. Click <a href="https://2014.igem.org/Team:Cambridge-JIC/Team">here</a> to meet the team.</p>
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                    <p class="lead">We are 9 Cambridge science undergraduates from various backgrounds and with all kinds of fascinating and curious interests. Click <a href="https://2014.igem.org/Team:Cambridge-JIC/Team">here</a> to learn more about the team.</p>
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Latest revision as of 01:17, 18 October 2014

Cambridge iGEM 2014

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mösbi - a plant biosensor for everyone

mӧsbi stands for marchantia open-source biosensor. mӧsbi encapsulates the team's vision of creating a user-friendly, open-source biosensor using the liverwort Marchantia polymorpha. With its sturdy genetic framework and modularity, mӧsbi represents a new step in popularising synthetic biology and making it accessible to a large audience. Click here to find out more.

Marchantia polymorpha as a new chassis

Marchantia polymorpha is our novel, eukaryotic multicellular chassis. Being a liverwort, it is one of the most primitive land plants around. Its small size and relative genetic simplicity make it easy to work with and an exciting new model organism in synthetic biology. Content to grow on agar plates, marchantia can be bioengineered in a standard lab with minimal extra equipment. Click here to find out more about the plant and our work to develop the chassis; and here to learn how to get started using Marchantia in your own iGEM project.

Results

We successfully transformed hundreds of individual plants, resulting in the first expression of chromoproteins in Marchantia, and probably the first expression of chromoproteins in any plant. We successfully built an arduino-controlled growth chamber, characterised an enzyme new to iGEM and amended the community's knowledge of an existing registry entry. A known Marchantia promoter was also added to the registry, along with 27 candidate promoters from the Marchantiagenome. They are part of a Marchantia starter kit part collection that also includes terminators, direction sequences, etc. Finally, we submitted an RFC with collaboration of two other iGEM teams, establishing a unified Type IIS based grammar for plant synthetic biologist: PlantSyntax. Click here for more result details, and here for our executive summary.

Our team

We are 9 Cambridge science undergraduates from various backgrounds and with all kinds of fascinating and curious interests. Click here to learn more about the team.

Retrieved from "http://2014.igem.org/Team:Cambridge-JIC"