Team:UMayor-Chile

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<div align="center"><a href="https://2014.igem.org/Team:UMayor-Chile" target="_blank"><img src="http://i57.tinypic.com/2e5uypz.png" border="0" alt="Image and video hosting by TinyPic"></a>
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<h1 >WELCOME TO iGEM 2014! </h1>
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<marquee>  <h1> <cente>  PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR </center> </h1>               </marquee> <span style="color:#FFFFFF"> CHILE
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<p>Your team has been approved and you are ready to start the iGEM season!
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<p>Hello world!! We are an official team for the iGEM 2014. We are working so hard on our project TroyHorse, but we're having a really good experience
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<p style="color:#yellow"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UMayor-Chile&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UMayor-Chile"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UMayor-Chile"style="color:#000000"> News and events </a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Notebook"style="color:#000000"> Notebook</a></td>
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<a href="https://2014.igem.org/Team:UMayor-Chile/Notebook"style="color:#000000"> Out the lab</a></td>
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<li><a href="https://2014.igem.org/Team:UMayor-Chile">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:UMayor-Chile/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=UMayor-Chile">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:UMayor-Chile/Project">Project</a> </li>
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<h3 style="color:#ffffff;">The Cystic Fibrosis (CF)</h3>
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<p>It’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.</p>
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<p>Visit the <a href="https://2014.igem.org/Wiki_How-To"> Wiki How To page </a> for a complete list of requirements, tips and other useful information. </p>
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<h3 style="color:#ffffff;">Fig 1: Construct that allows E. coli to weak Pseudomonas's biofilm.</h3>
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<p><a href="http://es.tinypic.com?ref=2d960zk" target="_blank"><img src="http://i60.tinypic.com/2d960zk.jpg" border="0" alt="Image and video hosting by TinyPic"></a></p>
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<h3 style="color:#ffffff;">Fig 2: Construct that allows E. coli to weak Pseudomonas's biofilm.</h3>
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<p><a href="http://es.tinypic.com?ref=2cz8xw6" target="_blank"><img src="http://i58.tinypic.com/2cz8xw6.jpg" border="0" alt="Image and video hosting by TinyPic"></a></p>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
 
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
 
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Latest revision as of 00:55, 18 October 2014


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PROJECT IGEM TROY HORSE - UNIVERSIDAD MAYOR

CHILE

Hello world!! We are an official team for the iGEM 2014. We are working so hard on our project TroyHorse, but we're having a really good experience

Click here to edit this page!

Home Team News and events Project Parts Modeling Out the lab Safety Attributions

The Cystic Fibrosis (CF)

It’s a mutation in the glycoprotein CFTR (that have a rol as a chloride channel), which affects the entire system, including the immune system. When a patient is diagnosticated with Pseudomonas aeruginosa in his lungs, it is too difficult to eradicate it. One reason of this it’s the biofilm generated by P. aerugunosa, which protects this opportunistic pathogen from any attack, including the treatments with antibiotics. Our project aims to generate a bacteria capable of weakening the biofilm breaking one of the main components of this protection: the arginate; and shutting down the communication between the Pseudomonas colonies. The E. coli is capable to use the biofilms, making it a good candidate for use as a Trojan horse. We going to test the above mentioned functions in this chassis, using in vitro biofilms.

Fig 1: Construct that allows E. coli to weak Pseudomonas's biofilm.

Image and video hosting by TinyPic