Team:TCU Taiwan

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<meta name="description" content="This WIKI Web is about TCU_Taiwan iGEM project in 2014.The International Genetically Engineered Machine competition (iGEM) is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells." />
<meta name="description" content="This WIKI Web is about TCU_Taiwan iGEM project in 2014.The International Genetically Engineered Machine competition (iGEM) is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells." />
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<h1 style="color:#F35A4A"><b><font face="Trebuchet MS" size="6">This Website currently under construction!</font></b></h1>
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<p><font face="Trebuchet MS" size="7" color="#A66B38">TCU_Taiwan</font></p><br>
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<p style="color:#F3F0CD"><font size="3" face="Verdana">Welcome to our new Internet domain!
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<p style="color:#90B849"><font size="4" face="Verdana">Welcome to our Wiki Page!
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<br>Our WIKI will be online soon.<br> Thank you for your patience while we build site.Please visit again.
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</font><p>Or go to
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<h3><a href="http://tcuigem.wordpress.com/" target="_blank">Our Blog</a> and    Facebook</h3>
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     <td align="center"><p><font face="Trebuchet MS" size="6" color="#9FE0F6"><img src="https://static.igem.org/mediawiki/2014/f/f4/TCU-Project-logo.png" width="65">&nbsp;Project Overview</font></p>
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     <td align="center"><br><br><p><font face="Trebuchet MS" size="7" color="#9FE0F6"><img src="https://static.igem.org/mediawiki/2014/f/f4/TCU-Project-logo.png" width="65">&nbsp;Project Overview</font></p>
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     <p align="left"><font size="3" face="Verdana" color="#F3F0CD" >Bacterial resistance to antibiotics has been a problem for public health, and the problem is getting worse.We are trying to develop a CRISPR system combined with phage transduction to solve this problem.<br><br>
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      This year, we are trying to develop a CRISPR system combined with phage transduction to solve bacteria's resistance to antibiotics. The type II CRISPR system is a powerful mechanism in gene engineering. This system has been proved to have more efficiency than other mechanisms such as zinc finger or TALEN. However CRISPR can only function within one cell, so we use M13 phage as vector to send our CRISPR into bacteria cells to cure their resistance for M13 is a lysogenic phage. In order to regulate our phage transduction, we use phagemid pBluescript and M13KO7 helper phage. The pBluescript contains our designed CRISPR system, it will produce CRISPR-transferd M13 phage only when a helper phage infect bacterium which have pBluescript. Then the engineered M13 phage will infect other bacteria and induce transduction of CRISPR system. Once we start the CRISPR, it will recognize and knock down the antibiotic resistance gene.</font></p>
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     <p align="justify"><font size="4" face="Verdana" color="#F3F0CD" >This year, TCU_Taiwan provide a new tool dealing with bacterial antibiotic resistance - the Trogene Horse. Our Trogene Horse can produce one-generation phage carrying CRISPR system with particular signal.</font></p>
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     <p align="justify"><font size="4" face="Verdana" color="#F3F0CD" >Trogene Horse is a new concept combining phage therapy with CRISPR, and this combination can solve both safety concern(phage therapy) and efficiency problem(CRISPR). We believe our project can deal with bacterial resistance problem on agriculture, and hope it can access on medicine one day.</font></p><br><br><br><br>
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     <td align="center"><font face="Trebuchet MS" size="6" color="#F3F0CD"><img src="https://static.igem.org/mediawiki/2014/c/cc/TCU-Anti.png" width="55px">For additional information , please click the boxes.</font></td>
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     <td align="center"><font face="Trebuchet MS" size="6" color="#F3F0CD">For additional information , please click the boxes.</font></td>
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<font size="5">Under construction!</font><br >
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<a href="https://static.igem.org/mediawiki/2014/9/95/TCU-Taiwan_An_Introduction_of_Trogene_Horse_%28720p%29.mov"><br>Download the video.</a>
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     <td style="background:#F2B441" align="center"><p><a href="https://2014.igem.org/Team:TCU_Taiwan/Modeling"><img src="https://static.igem.org/mediawiki/2014/3/3e/TCU-Modeling.GIF" width="100" height="100"></a></p>
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    <a href="http://english.moe.gov.tw/" title="Ministry of Education,Republic of China" target="_blank"><img src="https://static.igem.org/mediawiki/2014/8/83/TCU_Moe_logo_BLACK.png" height="100" onMouseMove="this.src=Image3.src" onMouseOut="this.src='https://static.igem.org/mediawiki/2014/8/83/TCU_Moe_logo_BLACK.png'"></a>&nbsp;&nbsp;&nbsp;
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    <a href="http://tec.tcu.edu.tw/100/" title="Center of Teaching Excellence,TCU" target="_blank"><img src="https://static.igem.org/mediawiki/2014/2/26/TCU_TEACH_BLACK.png" height="100" onMouseMove="this.src=Image1.src" onMouseOut="this.src='https://static.igem.org/mediawiki/2014/2/26/TCU_TEACH_BLACK.png'"></a>&nbsp;&nbsp;
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    <a href="http://www.tzuchi.org/" title="Buddhist Compassion Relief Tzu Chi Foundation" target="_blank"><img src="https://static.igem.org/mediawiki/2014/f/ff/TZUCHI_SUP_BLACK.png" height="90" onMouseMove="this.src=Image5.src" onMouseOut="this.src='https://static.igem.org/mediawiki/2014/f/ff/TZUCHI_SUP_BLACK.png'"></a>&nbsp;&nbsp;
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    <a href="http://eng.tcu.edu.tw/" title="Tzu Chi University" target="_blank"><img src="https://static.igem.org/mediawiki/2014/4/43/TCU_SUP_LOGO_BLACK.png" height="90" onMouseMove="this.src=Image4.src" onMouseOut="this.src='https://static.igem.org/mediawiki/2014/4/43/TCU_SUP_LOGO_BLACK.png'"></a>&nbsp;
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    <a href="https://2013.igem.org/Team:TzuChiU_Formosa" title="2013 TzuChiU_Formosa" target="_blank"><img src="https://static.igem.org/mediawiki/2014/7/75/2013_TCUIGEM_BLACK.png" height="130" onMouseMove="this.src=Image2.src" onMouseOut="this.src='https://static.igem.org/mediawiki/2014/7/75/2013_TCUIGEM_BLACK.png'"></a>
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Latest revision as of 21:35, 17 October 2014

TCU_Taiwan


Welcome to our Wiki Page!

 

 Project Overview


This year, TCU_Taiwan provide a new tool dealing with bacterial antibiotic resistance - the Trogene Horse. Our Trogene Horse can produce one-generation phage carrying CRISPR system with particular signal.

Trogene Horse is a new concept combining phage therapy with CRISPR, and this combination can solve both safety concern(phage therapy) and efficiency problem(CRISPR). We believe our project can deal with bacterial resistance problem on agriculture, and hope it can access on medicine one day.





  
For additional information , please click the boxes.

 

 

 

 

 

 

 




           



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