Team:Paris Bettencourt/Project

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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library">SMELL THE ROSES</a><div class=description><p> Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU">SOMETHING FISHY</a><div class=description><p>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor. Our project aims at engineering skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme trimethylamine monooxygenase (TMM).</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor">GOODY TWO SHOES</a><div class=description><p>Isovaleric acid, the cheesy component of foot odor, is produced by <i>B. subtilis</i> through the leucine degradation pathway. We characterize a <i>B. subtilis</i> mutant in this pathway, <i>in vitro</i> and <i>in situ</i> (on socks).</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell">DON'T SWEAT IT</a><div class=description><p>Armpit odor comes mainly from aminoacylase enzymes expressed in the genus Corynebacteria. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell">TEEN SPIRIT</a><div class=description><p>2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Art">DESIGN PRACTICE</a><div class=description><p>Science is beautiful.</p></div></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Bioinformatics">BIOINFORMATICS</a><div class=description><p>Here we mine human microbiome data to survey the frequency and diversity of genes related to body odor. The results suggest specific hotspots for odor gene variation.</p></div></td>
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<td><div id=main class=description><p>All humans have a body odor, but sometimes it is unwanted. Our core projects modify the natural human skin flora to change body odors associated with the armpit, foot, fish odor syndrome and old age.</p></div></td>
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<li><li><a href="https://2014.igem.org/Team:Paris_Bettencourt">+ Home </a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team">+ Team </a>
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<ul>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Attributions">+ Attributions</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Team">+Our Team</a></li>
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                                <li><a href="https://igem.org/Team.cgi?year=2014&team_name=Paris_Bettencourt" id = "link">+ Official Team Profile </a></li>
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                </li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project">+ Project</a>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Interlab_Study">Interlab Study</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project">Overall Project</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Citizen_Science">Gym Class Heroes</a></li>
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<li><a href="#">+ Achievement</a>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook">+ Notebook</a>
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                              <li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook">+Daily Note</a></li>
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                              <li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Protocols">+Protocols</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Safety" id = "link">+ Safety </a></li>
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<h1></h1>
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<h2>Paris Bettencourt 2014</h2>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library">+ Odor Library</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell">+ Old People Smell</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU">+ TMAU</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor" id="link">+ Foot Odor</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell" id="link">+ Eliminate Smell</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Gym_Class_Heroes" id="link">+ Gym Class Heroes</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Interlab_Study" id="link">+ Interlab Study</a></li>
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<h4>Project Description</h4>
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<h6 id=h6>It has always been the objective of iGEM Paris Bettencourt to conduct novel
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projects. This year, our team has decided to explore a topic that has rarely been
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approached by synthetic biologists in this competition: odor.
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Human olfaction relies on a tremendous number of cellular receptors that can
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detect specific molecules in the air. Upon the detection of combination of these
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compounds, a message is sent to the brain, which leads to the perception of one unique
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odor. There is considerable work left to do in order to understand the sense of smell,
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especially in determining how olfactory receptors operate.
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Few synthetic biologists have tried to engineer bacteria to produce smell or to
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treat bad smell since the production of odor by microorganisms is not studied often. One
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reason for the lack of study in this area is that it is hard to quantify and characterize an
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odor. We will overcome this by using odor professionals and commonly used scientific
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tools. We want to do this in order to investigate the links between our skin microbiota
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and body odor, as well as the perception of one's body odor by others.
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<h4>Subproject</h4>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library">Odor Library</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell">Old People Smell</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU">TMAU</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Citizen_Science">Gym Class Heroes</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell">Eliminate Smell</a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor">Foot Odor</a></li>
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        <li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Interlab_Study" id="link">Interlab Study</a></li>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=Paris_Bettencourt"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Project"style="color:#000000"> Project</a></td>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Modeling"style="color:#000000"> Modeling</a></td>
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<a href="https://2014.igem.org/Team:Paris_Bettencourt/Notebook"style="color:#000000"> Notebook</a></td>
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Latest revision as of 20:48, 17 October 2014

SMELL THE ROSES

Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.

 SOMETHING FISHY

Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor. Our project aims at engineering skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme trimethylamine monooxygenase (TMM).

 GOODY TWO SHOES

Isovaleric acid, the cheesy component of foot odor, is produced by B. subtilis through the leucine degradation pathway. We characterize a B. subtilis mutant in this pathway, in vitro and in situ (on socks).

 DON'T SWEAT IT

Armpit odor comes mainly from aminoacylase enzymes expressed in the genus Corynebacteria. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.

 TEEN SPIRIT

2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.

 DESIGN PRACTICE

Science is beautiful.

 BIOINFORMATICS

Here we mine human microbiome data to survey the frequency and diversity of genes related to body odor. The results suggest specific hotspots for odor gene variation.

All humans have a body odor, but sometimes it is unwanted. Our core projects modify the natural human skin flora to change body odors associated with the armpit, foot, fish odor syndrome and old age.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
Copyright (c) 2014 igem.org. All rights reserved.

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