Team:TCU Taiwan/FutureWorks

From 2014.igem.org

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     <td><font size="3" face="Verdana" color="#333"><p>In the future, we plan to make our Trogene  Horse become a substitute to antibiotics. Because antibiotic uses are forbidden  in some industry (ex. animal husbandry), there is no sense silencing resistance  gene in these parts.</p></font></td>
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     <td><font size="3" face="Verdana" color="#333"><p>In the future, we plan to make our Trogene  Horse become a substitute to antibiotics. Because antibiotic uses are forbidden  in some industry (ex. animal husbandry), there is no sense silencing resistance  gene in these parts.</p>
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     <td><font size="3" face="Verdana" color="#333"><p>We believe 16S rRNA gene can be the new taget of our Trogene Horse. The 16S rRNA gene is the most common housekeeping genetic marker, it has some special characters we are interested: </p>
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     <td><font size="3" face="Verdana" color="#333"><p>We believe 16S rRNA gene can be the new target of our Trogene Horse. The 16S rRNA gene is a housekeeping gene, it has some special characters we are interested: </p>
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         1. Its presence in almost all microbe, and its sequence remains high conservation.<br />
         1. Its presence in almost all microbe, and its sequence remains high conservation.<br />
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    2. The function of the  16S rRNA gene over time has not  changed (help constructing ribosome).</p></font></td>
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        2. The function of the  16S rRNA gene over time has not  changed (help constructing ribosome).</p>
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     <td><font size="3" face="Verdana" color="#333"><p>As 16S rRNA gene sequence is similar among species, it is possible to design a  gRNA targets all kinds of 16S rRNA gene. Because the 16S rRNA is necessary for  ribosome, knock-out of its gene will block gene expression and inhibit growth of target bacteria. This shall avoid co-effect of antibiotic use and remains high efficiency because we use phages as vector.</p></font></td>
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     <td><font size="3" face="Verdana" color="#333"><p>Because 16S rRNA is necessary for ribosome and it exists among microbes, knock-out of its gene will block gene expression and inhibit growth of target bacteria. This shall avoid co-effect of antibiotic use and remains high efficiency because we use phages as vector.</p>
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Latest revision as of 17:31, 17 October 2014


 
Future Works
  
 

In the future, we plan to make our Trogene Horse become a substitute to antibiotics. Because antibiotic uses are forbidden in some industry (ex. animal husbandry), there is no sense silencing resistance gene in these parts.
 
 

We believe 16S rRNA gene can be the new target of our Trogene Horse. The 16S rRNA gene is a housekeeping gene, it has some special characters we are interested:


1. Its presence in almost all microbe, and its sequence remains high conservation.
2. The function of the 16S rRNA gene over time has not changed (help constructing ribosome).
 
 

Because 16S rRNA is necessary for ribosome and it exists among microbes, knock-out of its gene will block gene expression and inhibit growth of target bacteria. This shall avoid co-effect of antibiotic use and remains high efficiency because we use phages as vector.
 

Reference: JOURNAL OF CLINICAL MICROBIOLOGY , Vol. 45, No. 9
 
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