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Team:ATOMS-Turkiye
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| - | < | + | <div class="asoContent"> |
| - | </ | + | <ul id="rightmenunew"> |
| + | <li><a href="https://2014.igem.org/Team:ATOMS-Turkiye/At-a-Glance"><img src="https://static.igem.org/mediawiki/2014/4/4f/ATOMS-Turkiye_right_1.png" /></a></li> | ||
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| + | <li><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Interlab-Study"><img src="https://static.igem.org/mediawiki/2014/5/58/ATOMS-Turkiye_right_3.png" /></a></li> | ||
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| - | < | + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/3/33/ATOMS-main-1.jpg/800px-ATOMS-main-1.jpg" title= "Our vessel tissue consists of three layers mainly: endothelium, muscular layer and outer layer. Nutrients and oxygen can pass through these layer to reach in other tissues. "></li> |
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-2.jpg" title= "In some cases such as excessive body weight or diabetes, fat accumulation may occur onto the endothelium which forms 'plaques' in time. "></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/8/84/ATOMS-main-3.jpg/800px-ATOMS-main-3.jpg" title= "This plaques may continue to grow and widen which ends up with narrowing of the lumen of vessel that decreases blood flow into the tissues and increases the tension."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/2/2a/ATOMS-main-4.jpg/800px-ATOMS-main-4.jpg" title= "This tension and other factors can result with the rupture of the plaques. This rupture then activates the coagulation cascade inside the blood."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/d/d7/ATOMS-main-5.jpg/800px-ATOMS-main-5.jpg" title= "Coagulation process ends with the formation of a clot. Due to other factors related with plaque formation, this clot tends to grow larger."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/1b/ATOMS-main-6.jpg/800px-ATOMS-main-6.jpg" title= "Sometimes this clot may block the bloodstream completely. This results with the disruption of blood supply to the distal tissue."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/1/15/ATOMS-main-7.jpg/800px-ATOMS-main-7.jpg" title= "As blood contains oxygen and nutrient which are essential for energy production, tissue becomes depleted of energy and oxygen, which is called hypoxia. This may end with tissue death if it longs further."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/c/ca/ATOMS-main-8.jpg/800px-ATOMS-main-8.jpg" title= "In our project, our engineered endothelial cells can sense this hypoxia in early stages and become activated to solve the problem."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/f/fe/ATOMS-main-8a.jpg/800px-ATOMS-main-8a.jpg" title= "Engineered cells start to secrete clot dissolving factors into bloodstream to restore the blood supply to the tissue. Meanwhile they prepare for additonal damage to the oxidative burst after the restoration of oxygen."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/a/aa/ATOMS-main-9.jpg/800px-ATOMS-main-9.jpg" title= "As clot becomes dissolved gradually, partial blood supply can be established which may cause oxidative burst. This effect is also prevented by our cells."></li> | ||
| + | <li><img src="https://static.igem.org/mediawiki/2014/thumb/7/78/ATOMS-main-10.jpg/800px-ATOMS-main-10.jpg" title= "With these sensing and protective systems, hypoxic conditions can be treated without the evaluation of clinical presence. "></li> | ||
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| - | + | </div> | |
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| + | <h2>Project Abstract</h2> | ||
| + | <p><a href="#"></a>Tissue hypoxia, or ischemia, is the condition that describes the poor conveyance of oxygen and other vital products to body tissues and organs which consequently results tissue death. Up to now, the number one cause of death worldwide is caused by ischemia and related conditions such as heart attack or stroke. It is needed to regard the big picture of the condition in order to solve the problem. In our project, our will is to build two different devices, which work synergistically, to fix these two distinct situations. We decided to use ‘’hypoxia inducible systems” and ‘’reactive oxygen species (ROS) sensitive gene fragments’’. These two receptors will hopefully regulate the release of clot dissolving factors and antioxidant peptides synthesized by our engineered vessel cells. We hope to bring encouraging results in vitro to pave the way of this promising system into the lifesaving remedy method.</p> | ||
| + | </div> | ||
| - | <div | + | <div id="cont"> |
| + | <div class="shwnews"> | ||
| + | <ul> | ||
| + | <li class="one"> | ||
| + | <div><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Modeling" class="tit">Modeling</a><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Modeling" class="lnk"><span><strong>This year, we have carried out a mathematical modeling to understand how our promoter system would react against hypoxia to be able to treat heart problems. To learn more, click here</strong></span></a> | ||
| - | the | + | <img src="https://static.igem.org/mediawiki/2014/0/03/ATOMS-Modelling1.png" alt="This is the place of Modeling results" width="210" height="220"><b>This is the place of Modeling results...</b> |
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| + | </li> | ||
| + | <li class="two"> | ||
| + | <div><a href="https://2014.igem.org/Team:ATOMS-Turkiye/BioBricks#main" class="tit">BioBricks</a><a href="https://2014.igem.org/Team:ATOMS-Turkiye/BioBricks#main" class="lnk"><span><strong>Our team proposes seven new eukaryotic cell parts to the Registry consisting of three promoters and four different enzymes with various capabilities. To get detailed information, proceed here.</strong></span></a> | ||
| - | + | <img src="https://static.igem.org/mediawiki/2014/1/16/Atoms_turkiye_main_page_diagram.jpg" alt="This is a comprehensive wiev of project" width="210" height="220"><b>This is a comprehensive wiev of project...</b> | |
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| - | + | <div><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Achievements" class="tit">Achievements</a><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Achievements" class="lnk"><span><strong>It was a long study session; but it's worth. We accomplished several of our tasks to establish a fully beneficial treatment for heart attacks. To check out what we achieve, click here.</strong></span></a> | |
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| + | <img src="https://static.igem.org/mediawiki/2014/e/e5/Atoms_turkiye_biobricks_odd_small.jpg" alt="Mechanism of ODD..." width="210" height="220"><b>It was a long study session; but...</b> | ||
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Revision as of 13:39, 17 October 2014
Project Abstract
Tissue hypoxia, or ischemia, is the condition that describes the poor conveyance of oxygen and other vital products to body tissues and organs which consequently results tissue death. Up to now, the number one cause of death worldwide is caused by ischemia and related conditions such as heart attack or stroke. It is needed to regard the big picture of the condition in order to solve the problem. In our project, our will is to build two different devices, which work synergistically, to fix these two distinct situations. We decided to use ‘’hypoxia inducible systems” and ‘’reactive oxygen species (ROS) sensitive gene fragments’’. These two receptors will hopefully regulate the release of clot dissolving factors and antioxidant peptides synthesized by our engineered vessel cells. We hope to bring encouraging results in vitro to pave the way of this promising system into the lifesaving remedy method.
This is the place of Modeling results...
This is a comprehensive wiev of project...
It was a long study session; but...
