Team:Groningen/Template/MODULE/projects/parts/secretion

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System against Biofilm
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When optimistic bacteria infect start infection a wound they often protect themselves with a biofilm. For an effective fight against these infections the biofilm should be broken down. We have assembled a biobrick of dispersinB fused to an USP45tag (BBa_K1365111).  This part is later assembled in the secretion system agains both <i> Staphylococcus aureus</i> and <i>Pseudonomas aeruginosa </i>.
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Secrection system against Pseudonomas aeruginosa
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We will fight against P. aeruginosa with an dual action system (BBa_K1365120). We assembled from exciting and novel biobricks a system which is able to produce dispersinB and aiiA (BBa_K1365169). The latter is an quorum quenching enzyme which disrupt communication between P. By doing this we try reduce their activity of both dividing and activating their pathogenic genes (source).   
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Secrection system against Staphylococcus aureus
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The cell wall of the gram-positive bacteria Staphylococcus aures contains Lipid-2 fatty acids. These are perfect targets for the anti-microbial nisin. We designed and assembled nisin in an a novel biobrick (BBa_K1365100) and in the same brick we included the dispersinB gene. With this, again, dual action system, we want to fight of S. aureus.
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Learn more about subjects
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More about;
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<a href="http://parts.igem.org/Part:BBa_K1365999"> dispersinB (dspB)</a>
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More about;
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<a href="http://parts.igem.org/Part:BBa_K1365999"> nisin </a>
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More about;
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<a href="http://parts.igem.org/Part:BBa_K1365999"> quorum quenching molecule (aiiA)</a></div>
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Revision as of 21:36, 16 October 2014

System against Biofilm
 
When optimistic bacteria infect start infection a wound they often protect themselves with a biofilm. For an effective fight against these infections the biofilm should be broken down. We have assembled a biobrick of dispersinB fused to an USP45tag (BBa_K1365111). This part is later assembled in the secretion system agains both Staphylococcus aureus and Pseudonomas aeruginosa .
 
Secrection system against Pseudonomas aeruginosa
 
We will fight against P. aeruginosa with an dual action system (BBa_K1365120). We assembled from exciting and novel biobricks a system which is able to produce dispersinB and aiiA (BBa_K1365169). The latter is an quorum quenching enzyme which disrupt communication between P. By doing this we try reduce their activity of both dividing and activating their pathogenic genes (source).
 
Secrection system against Staphylococcus aureus
 
The cell wall of the gram-positive bacteria Staphylococcus aures contains Lipid-2 fatty acids. These are perfect targets for the anti-microbial nisin. We designed and assembled nisin in an a novel biobrick (BBa_K1365100) and in the same brick we included the dispersinB gene. With this, again, dual action system, we want to fight of S. aureus.
 
Learn more about subjects
 
More about; dispersinB (dspB) More about; nisin More about; quorum quenching molecule (aiiA)
 
 
 
 

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