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| - | System against Biofilm
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| - | When optimistic bacteria infect start infection a wound they often protect themselves with a biofilm. For an effective fight against these infections the biofilm should be broken down. We have assembled a biobrick of dispersinB fused to an USP45tag (BBa_K1365111). This part is later assembled in the secretion system agains both <i> Staphylococcus aureus</i> and <i>Pseudonomas aeruginosa </i>.
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| - | Secrection system against Pseudonomas aeruginosa
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| - | We will fight against P. aeruginosa with an dual action system (BBa_K1365120). We assembled from exciting and novel biobricks a system which is able to produce dispersinB and aiiA (BBa_K1365169). The latter is an quorum quenching enzyme which disrupt communication between P. By doing this we try reduce their activity of both dividing and activating their pathogenic genes (source).
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| - | Secrection system against Staphylococcus aureus
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| - | The cell wall of the gram-positive bacteria Staphylococcus aures contains Lipid-2 fatty acids. These are perfect targets for the anti-microbial nisin. We designed and assembled nisin in an a novel biobrick (BBa_K1365100) and in the same brick we included the dispersinB gene. With this, again, dual action system, we want to fight of S. aureus.
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| - | Learn more about subjects
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| - | More about;
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| - | <a href="http://parts.igem.org/Part:BBa_K1365999"> dispersinB (dspB)</a></div>
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| - | More about;
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| - | <a href="http://parts.igem.org/Part:BBa_K1365999"> nisin </a></div>
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| - | More about;
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| - | <a href="http://parts.igem.org/Part:BBa_K1365999"> quorum quenching molecule (aiiA)</a></div>
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