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Team:UST Beijing
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| - | + | <html lang="en"> | |
| + | <head> | ||
| + | <meta charset="utf-8"> | ||
| + | <meta http-equiv="X-UA-Compatible" content="IE=edge"> | ||
| + | <meta name="viewport" content="width=device-width, initial-scale=1"> | ||
| + | <meta name="description" content=""> | ||
| + | <meta name="author" content=""> | ||
| + | <title>USTB iGEM14 Home</title> | ||
| - | < | + | <!-- Bootstrap core CSS --> |
| - | < | + | <link href="https://2014.igem.org/Team:UST_Beijing/bootstrap/bootstrap.css?action=raw&ctype=text/css" rel="stylesheet"> |
| - | < | + | <link href="https://2014.igem.org/Team:UST_Beijing/bootstrap/docs.css?action=raw&ctype=text/css" rel="stylesheet"> |
| - | |||
| - | |||
| - | < | + | <!-- HTML5 shim and Respond.js IE8 support of HTML5 elements and media queries --> |
| - | < | + | <!--[if lt IE 9]> |
| - | < | + | <script src="https://oss.maxcdn.com/html5shiv/3.7.2/html5shiv.min.js"></script> |
| + | <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> | ||
| + | <![endif]--> | ||
| + | <!-- Custom styles for this template --> | ||
| - | < | + | <style> |
| - | + | ||
| - | + | #footerlogo { | |
| - | + | width: 250px; | |
| + | height: 100px; | ||
| + | } | ||
| - | + | /* Removes default elements */ | |
| - | + | #contentSub, #footer-box, #sitesub, #catlinks, #search-controls, #p-logo, .printfooter, .firstHeading, .visualClear { | |
| + | display:none; | ||
| + | } | ||
| - | + | #top-section { | |
| - | + | border: none; | |
| + | height: 0px; | ||
| + | margin: 0px; | ||
| + | } | ||
| - | + | #content { | |
| - | + | border: none; | |
| + | background: transparent; | ||
| + | width: 100%; | ||
| + | padding: 0px; | ||
| + | } | ||
| - | + | p { | |
| - | + | margin: 0px; | |
| + | padding: 0px; | ||
| + | } | ||
| - | + | body { | |
| - | + | margin: 0 0 0 0; | |
| + | padding: 0; | ||
| + | } | ||
| - | + | html, body { | |
| - | + | width: auto !important; | |
| + | overflow-x: hidden !important; | ||
| + | height: 100% !important; | ||
| + | -webkit-overflow-scrolling: touch; | ||
| + | } | ||
| - | + | #top-section { | |
| - | + | width: 1140px; | |
| + | height: 0; | ||
| + | margin: 0 auto; | ||
| + | padding: 0; | ||
| + | border: none; | ||
| + | } | ||
| + | #menubar { | ||
| + | font-size: 80%; | ||
| + | top: 0px; | ||
| + | margin: 0px; | ||
| - | + | /* Resizes the menubar to fix the links (default is 400px) */ | |
| - | + | width: auto; | |
| - | + | } | |
| - | + | .left-menu:hover { | |
| - | + | background-color: transparent; | |
| + | } | ||
| - | + | #menubar li a { | |
| + | background: transparent; | ||
| + | color: transparent; | ||
| + | } | ||
| - | + | #menubar:hover li a { | |
| + | background-color: rgba(255, 255, 255, 0.8); | ||
| + | color: grey; | ||
| + | } | ||
| - | + | /* Removes "teams" from the menubar */ | |
| - | + | ||
| - | + | ||
| - | + | #menubar > ul > li:last-child { | |
| - | + | display: none;} | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | |||
| - | + | /* Customize the navbar*/ | |
| - | + | /* Special class on .container surrounding .navbar, used for positioning it into place. */ | |
| - | + | .navbar-wrapper { | |
| + | position: absolute; | ||
| + | top: 0; | ||
| + | right: 0; | ||
| + | left: 0; | ||
| + | z-index: 20; | ||
| + | } | ||
| - | + | /* Flip around the padding for proper display in narrow viewports */ | |
| + | .navbar-wrapper > .container { | ||
| + | padding-right: 0; | ||
| + | padding-left: 0; | ||
| + | } | ||
| + | .navbar-wrapper .navbar { | ||
| + | padding-right: 15px; | ||
| + | padding-left: 15px; | ||
| + | } | ||
| + | .navbar-wrapper .navbar .container { | ||
| + | width: auto; | ||
| + | } | ||
| - | + | /* Customize the carousal */ | |
| - | + | ||
| - | + | /* Carousel base class */ | |
| - | + | .carousel { | |
| + | height: 650px; | ||
| + | margin-bottom: 60px; | ||
| + | } | ||
| + | /* Since positioning the image, we need to help out the caption */ | ||
| + | .carousel-caption { | ||
| + | z-index: 10; | ||
| + | } | ||
| - | + | /* Declare heights because of positioning of img element */ | |
| - | + | .carousel .item { | |
| - | + | height: 650px; | |
| + | background-color: #777; | ||
| + | } | ||
| + | .carousel-inner > .item > img { | ||
| + | position: absolute; | ||
| + | top: 0; | ||
| + | left: 0; | ||
| + | min-width: 100%; | ||
| + | height: 650px; | ||
| + | } | ||
| - | + | ||
| - | <p> | + | |
| - | < | + | /* Content */ |
| - | </p> | + | |
| + | /* Center align the text within the three columns below the carousel */ | ||
| + | .marketing .col-lg-4 { | ||
| + | margin-bottom: 20px; | ||
| + | text-align: center; | ||
| + | } | ||
| + | .marketing h2 { | ||
| + | font-weight: normal; | ||
| + | } | ||
| + | .marketing .col-lg-4 p { | ||
| + | margin-right: 10px; | ||
| + | margin-left: 10px; | ||
| + | } | ||
| + | |||
| + | |||
| + | /* Featurettes */ | ||
| + | |||
| + | .featurette-divider { | ||
| + | margin: 80px 0; /* Space out the Bootstrap <hr> more */ | ||
| + | } | ||
| + | |||
| + | /* Thin out the marketing headings */ | ||
| + | .featurette-heading { | ||
| + | font-weight: 300; | ||
| + | line-height: 1; | ||
| + | letter-spacing: -1px; | ||
| + | } | ||
| + | |||
| + | |||
| + | |||
| + | /* Responsive CSS */ | ||
| + | |||
| + | @media (min-width: 768px) { | ||
| + | |||
| + | /* Navbar positioning foo */ | ||
| + | .navbar-wrapper { | ||
| + | margin-top: 20px; | ||
| + | } | ||
| + | .navbar-wrapper .container { | ||
| + | padding-right: 15px; | ||
| + | padding-left: 15px; | ||
| + | } | ||
| + | .navbar-wrapper .navbar { | ||
| + | padding-right: 0; | ||
| + | padding-left: 0; | ||
| + | } | ||
| + | |||
| + | /* The navbar becomes detached from the top, so we round the corners */ | ||
| + | .navbar-wrapper .navbar { | ||
| + | border-radius: 4px; | ||
| + | } | ||
| + | |||
| + | /* Bump up size of carousel content */ | ||
| + | .carousel-caption p { | ||
| + | margin-bottom: 20px; | ||
| + | font-size: 21px; | ||
| + | line-height: 1.4; | ||
| + | } | ||
| + | |||
| + | .featurette-heading { | ||
| + | font-size: 50px; | ||
| + | } | ||
| + | } | ||
| + | |||
| + | @media (min-width: 992px) { | ||
| + | .featurette-heading { | ||
| + | margin-top: 120px; | ||
| + | } | ||
| + | } | ||
| + | |||
| + | </style> | ||
| + | |||
| + | </head> | ||
| + | |||
| + | <!-- navbar --> | ||
| + | |||
| + | <body> | ||
| + | <div class="navbar-wrapper"> | ||
| + | <div class="container"> | ||
| + | |||
| + | <div class="navbar navbar-inverse navbar-static-top" role="navigation"> | ||
| + | <div class="container"> | ||
| + | <div class="navbar-header"> | ||
| + | <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target=".navbar-collapse"> | ||
| + | <span class="sr-only">Toggle navigation</span> | ||
| + | <span class="icon-bar"></span> | ||
| + | <span class="icon-bar"></span> | ||
| + | <span class="icon-bar"></span> | ||
| + | </button> | ||
| + | <a class="navbar-brand" href="https://2014.igem.org/Team:UST_Beijing">USTB iGEM14</a> | ||
| + | </div> | ||
| + | <div class="navbar-collapse collapse"> | ||
| + | <ul class="nav navbar-nav"> | ||
| + | <li class="active"><a href="https://2014.igem.org/Team:UST_Beijing">Home</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Team">Team</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Project">Project</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Parts">Parts</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Modeling">Modeling</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Outreach">Outreach</a></li> | ||
| + | |||
| + | <li class="dropdown"> | ||
| + | <a href="#notebook" class="dropdown-toggle" data-toggle="dropdown">Notebook <span class="caret"></span></a> | ||
| + | <ul class="dropdown-menu" role="menu"> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Footsteps">Footsteps</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Safety">Safety</a></li> | ||
| + | <li><a href="https://2014.igem.org/Team:UST_Beijing/Attributions">Attributions</a></li> | ||
| + | </ul> | ||
| + | </li> | ||
| + | </ul> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | |||
| + | </div> | ||
| + | </div> | ||
| + | |||
| + | <!-- Carousel --> | ||
| + | <div id="myCarousel" class="carousel slide" data-ride="carousel"> | ||
| + | <div class="carousel-inner"> | ||
| + | <div class="item active" style="background: url(https://static.igem.org/mediawiki/2014/3/35/Home_back2.jpg) no-repeat center center; background-size: cover;"> | ||
| + | <div class="container"> | ||
| + | <div class="carousel-caption"> | ||
| + | <h1>Learn from ancestors.</h1> | ||
| + | <p class="lead">An undesirable mutation deprived one of our beloved magics - providing vitamin C for ourselves. Fortunately, we might be able to pick it up from our ancestors.</p> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div><!-- /.carousel --> | ||
| + | |||
| + | |||
| + | <div class="bs-docs-featurette"> | ||
| + | <div class="container"> | ||
| + | <h2 class="bs-docs-featurette-title">Through evolution, we lost something.</h2> | ||
| + | <p class="lead">Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. We have, however, lost some magical potentials in this process. The capability to generate vitamin C for ourselves is one of the lost magics. </p> | ||
| + | |||
| + | <hr class="half-rule"> | ||
| + | |||
| + | <div class="row"> | ||
| + | <div class="col-sm-4"> | ||
| + | <img id="monkey" src="https://static.igem.org/mediawiki/2014/2/26/Monkey1.png" alt="" class="img-responsive"> | ||
| + | <h3>Ancestors</h3> | ||
| + | <p align="left">Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.</p> | ||
| + | </div> | ||
| + | <div class="col-sm-4"> | ||
| + | <img id="human1" src="https://static.igem.org/mediawiki/2014/0/03/Monkey4.png" alt="" class="img-responsive"> | ||
| + | <h3>We Human</h3> | ||
| + | <p align="left">Vitamin C has been playing a pivotal role in scavenging free radical and collagen synthesis. People with long-time insufficient ingestion of vitamin C, sailors for instance, could suffer from scurvy disease. To make matters worse, accumulation of free radical could be an important factor of aging.</p> | ||
| + | </div> | ||
| + | <div class="col-sm-4"> | ||
| + | <img id="human2" src="https://static.igem.org/mediawiki/2014/3/3d/Monkey3.png" alt="" class="img-responsive"> | ||
| + | <h3>Solutions?</h3> | ||
| + | <p align="left">The truth is, we lost the ability to provide an indispensable vitamin to ourselves. And here's what we are working around: can we find out a way to reactivate GLO gene and express functional GLO, hence pick up our long-lost magic? We've conducted cell-level experiments and evaluated their possible effects.</p> | ||
| + | </div> | ||
| + | </div> | ||
| + | |||
| + | </div> | ||
| + | </div> | ||
| + | |||
| + | |||
| + | <div class="bs-docs-featurette"> | ||
| + | <div class="container"> | ||
| + | <h2 class="bs-docs-featurette-title">The answer is fusion.</h2> | ||
| + | <p class="lead">Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing vitamin C, just like our ancestors. However, there's still a long way to go.</p> | ||
| + | |||
| + | <div class="row"> | ||
| + | |||
| + | <div class="col-sm-4"> | ||
| + | <img src="https://static.igem.org/mediawiki/2014/b/b5/Monkeygene.png" alt="" class="img-responsive"> | ||
| + | </div> | ||
| + | |||
| + | <div class="col-sm-4"> | ||
| + | <img src="https://static.igem.org/mediawiki/2014/2/23/Genefused.png" alt="" class="img-responsive"> | ||
| + | </div> | ||
| + | |||
| + | <div class="col-sm-4"> | ||
| + | <img src="https://static.igem.org/mediawiki/2014/3/34/Humangene.png" alt="" class="img-responsive"> | ||
| + | </div> | ||
| + | |||
| + | <hr class="half-rule"> | ||
| + | |||
| + | |||
| + | <a href="https://2014.igem.org/Team:UST_Beijing/Project" class="btn btn-outline btn-lg">View our project</a> | ||
| + | |||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | |||
| + | |||
| + | <!--<div style="width:100%; height:40px; border:0; background-color: #ffffff;"></div> --> | ||
| + | |||
| + | |||
| + | |||
| + | <!-- Footer --> | ||
| + | |||
| + | <footer class="bs-docs-footer" role="contentinfo"> | ||
| + | <div class="container"> | ||
| + | |||
| + | <div align="center"><img id="footerlogo" src="https://static.igem.org/mediawiki/2014/7/74/Headerlogo.png" alt="" class="img-responsive"></div> | ||
| + | |||
| + | <p><br></p> | ||
| + | |||
| + | <p><font size=2.5>Built with love<br>By the iGEM14 team of <a href="http://www.ustb.edu.cn/">University of Science and Technology Beijing</a></font></p> | ||
| + | </font> | ||
| + | </ul> | ||
| + | </div> | ||
| + | </footer> | ||
| + | |||
| + | |||
| + | <!-- Bootstrap core JavaScript --> | ||
| + | |||
| + | <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script> | ||
| + | <script src="https://2014.igem.org/Team:UST_Beijing/bootstrap/bootstrap.js?action=raw"></script> | ||
| + | <script src="https://2014.igem.org/Team:UST_Beijing/bootstrap/docs.js?action=raw"></script> | ||
| + | |||
| + | </body> | ||
| + | </html> | ||
Latest revision as of 18:40, 16 October 2014
Learn from ancestors.
An undesirable mutation deprived one of our beloved magics - providing vitamin C for ourselves. Fortunately, we might be able to pick it up from our ancestors.
Through evolution, we lost something.
Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. We have, however, lost some magical potentials in this process. The capability to generate vitamin C for ourselves is one of the lost magics.
Ancestors
Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.
We Human
Vitamin C has been playing a pivotal role in scavenging free radical and collagen synthesis. People with long-time insufficient ingestion of vitamin C, sailors for instance, could suffer from scurvy disease. To make matters worse, accumulation of free radical could be an important factor of aging.
Solutions?
The truth is, we lost the ability to provide an indispensable vitamin to ourselves. And here's what we are working around: can we find out a way to reactivate GLO gene and express functional GLO, hence pick up our long-lost magic? We've conducted cell-level experiments and evaluated their possible effects.
The answer is fusion.
Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing vitamin C, just like our ancestors. However, there's still a long way to go.
