Team:UST Beijing

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<li><a href="https://2014.igem.org/Team:UST_Beijing">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:UST_Beijing/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=UST_Beijing">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:UST_Beijing/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:UST_Beijing/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:UST_Beijing/Safety">Safety</a> </li>
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<p>Synthetic biology is an emerging field which combines forward-engineering technology with that of conventional biochemical and molecular genetics approaches, also considered “reverse engineering” of terrestrial life systems. Since first established in 2003, the iGEM competition, a college level education platform, encourages the practice of genetic engineering using standardized function-oriented DNA fragments; in recent years especially, iGEM projects have become increasingly sophisticated, and some winning ones have reached the limit of logical reasoning and design. </p>
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<p>Our 2011 UST-Beijing team took the initiative of exploring horizontal gene transfer, by inserting a bacterial light-driven proton-pump into the inner mitochondrial membrane of cultured human cells. This year, for the 2014 iGEM competition, our UST-Beijing team will continue to analyze the transformed human cells, and make further proposals based on the unique observation of these experiments, in order to promote health and human welfare. </p>
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              <a class="navbar-brand" href="https://2014.igem.org/Team:UST_Beijing">USTB iGEM14</a>
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                      <li><a href="https://2014.igem.org/Team:UST_Beijing/Footsteps">Footsteps</a></li>
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              <h1>Learn from ancestors.</h1>
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              <p class="lead">An undesirable mutation deprived one of our beloved magics - providing vitamin C for ourselves. Fortunately, we might be able to pick it up from our ancestors.</p>
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    <h2 class="bs-docs-featurette-title">Through evolution, we lost something.</h2>
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    <p class="lead">Looking back at the footsteps of evolution, we human being exploit our limits and potentials to adapt mercurial environment and harsh conditions. We have, however, lost some magical potentials in this process. The capability to generate vitamin C for ourselves is one of the lost magics. </p>
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        <h3>Ancestors</h3>
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        <p align="left">Mutations in L-gulono-gama-lactone oxidase(GLO) gene in many vertebrate species caused the lack of expression of GLO, which leads to a loss of capability to produce vitamin C. As a result of this mutation, many species including human being developed their dependence on food source vitamin C.</p>
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        <h3>We Human</h3>
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        <p align="left">Vitamin C has been playing a pivotal role in scavenging free radical and collagen synthesis. People with long-time insufficient ingestion of vitamin C, sailors for instance, could suffer from scurvy disease. To make matters worse, accumulation of free radical could be an important factor of aging.</p>
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        <h3>Solutions?</h3>
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        <p align="left">The truth is, we lost the ability to provide an indispensable vitamin to ourselves. And here's what we are working around: can we find out a way to reactivate GLO gene and express functional GLO, hence pick up our long-lost magic? We've conducted cell-level experiments and evaluated their possible effects.</p>
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    <h2 class="bs-docs-featurette-title">The answer is fusion.</h2>
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    <p class="lead">Lemur catta，also called Lemur, is a kind of monkey and one of the two species of anthropoids with full and functional GLO gene. Lemur could be a good source of GLO gene if intend to regain our capability of producing vitamin C, just like our ancestors. However, there's still a long way to go.</p>
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      <a href="https://2014.igem.org/Team:UST_Beijing/Project" class="btn btn-outline btn-lg">View our project</a>
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  <p><font size=2.5>Built with love<br>By the iGEM14 team of <a href="http://www.ustb.edu.cn/">University of Science and Technology Beijing</a></font></p>
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Latest revision as of 18:40, 16 October 2014

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