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Team:Groningen/Template/MODULE/home
From 2014.igem.org
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| - | </html>{{:Team:Groningen/Template/MODULE/tmpl_imagemodule| | + | </html>{{:Team:Groningen/Template/MODULE/tmpl_imagemodule|English Abstract:|c/ce/Homepageabstractart.art.png| |
| - | + | <b> LactoAid - A smart bandage for burnwounds</b><br> | |
| + | <a href="https://2014.igem.org/Team:Groningen:abstract">See our abstract in 11 languages!</a><br> | ||
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Infections caused by <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> often pose problems for burn wound treatments. We developed a new kind of bandage that prevents these infections and reduces the use of antibiotics, thereby lowering the risk of developing antibiotic resistance. The bandage consists of a hydrogel that contains genetically engineered <i>Lactococcus lactis</i> with nutrients. The engineered strain of <i>L. lactis</i> detects the quorum sensing molecules of the two pathogens in the wound and subsequently produces the antimicrobial nisin as well as some other Infection-Preventing-Molecules (IPMs). These IPMs are the anti-biofilm protein Dispersin B and the quorum quenching protein AHLase. The gel is placed between two layers, a top layer to allow diffusion of gases and a bottom layer to contain the bacteria within the bandage. Hydrating the gel by breaking adjacent water pockets initiates the growth of the bacteria, thereby activating the bandage. | Infections caused by <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> often pose problems for burn wound treatments. We developed a new kind of bandage that prevents these infections and reduces the use of antibiotics, thereby lowering the risk of developing antibiotic resistance. The bandage consists of a hydrogel that contains genetically engineered <i>Lactococcus lactis</i> with nutrients. The engineered strain of <i>L. lactis</i> detects the quorum sensing molecules of the two pathogens in the wound and subsequently produces the antimicrobial nisin as well as some other Infection-Preventing-Molecules (IPMs). These IPMs are the anti-biofilm protein Dispersin B and the quorum quenching protein AHLase. The gel is placed between two layers, a top layer to allow diffusion of gases and a bottom layer to contain the bacteria within the bandage. Hydrating the gel by breaking adjacent water pockets initiates the growth of the bacteria, thereby activating the bandage. | ||
Revision as of 10:03, 16 October 2014
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English Abstract:
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