Team:ATOMS-Turkiye/asoMain

From 2014.igem.org

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<li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-1.jpg" title= "Our vessel tissue consists of three layers mainly: endothelium, muscular layer and outer layer. Nutrients and oxygen can pass through these layer to reach in other tissues. "></li>
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<li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-1.jpg/800px-ATOMS-main-1.jpg" title= "Our vessel tissue consists of three layers mainly: endothelium, muscular layer and outer layer. Nutrients and oxygen can pass through these layer to reach in other tissues. "></li>
  <li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-2.jpg" title= "In some cases such as excessive body weight or diabetes, fat accumulation may occur onto the endothelium which forms 'plaques' in time. "></li>
  <li><img src="https://static.igem.org/mediawiki/2014/thumb/6/6c/ATOMS-main-2.jpg/800px-ATOMS-main-2.jpg" title= "In some cases such as excessive body weight or diabetes, fat accumulation may occur onto the endothelium which forms 'plaques' in time. "></li>
  <li><img src="https://static.igem.org/mediawiki/2014/thumb/8/84/ATOMS-main-3.jpg/800px-ATOMS-main-3.jpg" title= "This plaques may continue to grow and widen which ends up with narrowing of the lumen of vessel that decreases blood flow into the tissues and increases the tension."></li>
  <li><img src="https://static.igem.org/mediawiki/2014/thumb/8/84/ATOMS-main-3.jpg/800px-ATOMS-main-3.jpg" title= "This plaques may continue to grow and widen which ends up with narrowing of the lumen of vessel that decreases blood flow into the tissues and increases the tension."></li>

Revision as of 01:30, 16 October 2014


Abstract

Tissue hypoxia, or ischemia, is the condition that describes the poor conveyance of oxygen and other vital products to body tissues and organs which consequently results tissue death. Up to now, the number one cause of death worldwide is caused by ischemia and related conditions such as heart attack or stroke. It is needed to regard the big picture of the condition in order to solve the problem. In our project, our will is to build two different devices, which work synergistically, to fix these two distinct situations. We decided to use ‘’hypoxia inducible systems” and ‘’reactive oxygen species (ROS) sensitive gene fragments’’. These two receptors will hopefully regulate the release of clot dissolving factors and antioxidant peptides synthesized by our engineered vessel cells. We hope to bring encouraging results in vitro to pave the way of this promising system into the lifesaving remedy method.

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