Team:Tianjin/Safety
From 2014.igem.org
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<a href="https://2014.igem.org/Team:Tianjin/Project" class="STYLE48">Project|</a></div></td> | <a href="https://2014.igem.org/Team:Tianjin/Project" class="STYLE48">Project|</a></div></td> | ||
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- | <td bgcolor="#993300">< | + | <td bgcolor="#993300"><span class="STYLE33"> Curli fiber expressed by the bacterium Escherichia coli is a bacterial form of amyloid. Amyloid fibers are associated with a variety of disease states, including prion diseases and systemic amyloidosis. Curli fiber has a strong adhesive power,?? can combine with the surface material of many organisms, including fiber mucin, laminin, plasminogen and so on. Vitro and in vivo tests showed that those bacteria? that be able to produce curli produce more virulence than bacteria that don’t produce curli, including adhesion, planting and invasion capacity of the host cell. E. Coli can produce curli fiber in its mammalian host, which may bring related <a href="C://Users/lihuize/AppData/Local/Yodao/DeskDict/frame/20140810194504/javascript:void(0);"></a> inflammation like sepsis to its hosts. Luckily, the synthetic curli fiber in our project is used outside of our body, so it will not bring such safety problem. Besides, in the intact bacterium, the expression of curli requires the concerted action of several gene products. Understanding how curli are assembled may help in our understanding of pathological amyloids in human disease.<br /> |
- | + | Our project could be used to make bioelectric detection, which could be applied in? the detection of some harmful substances to the environment or our body. We hope it could make great contribution to some hazardous substances’ safety problems in the near future.<br /> | |
- | + | <span class="STYLE72"><strong>References</strong></span><br /> | |
- | + | [1]Synthetic Biologists Design ‘Living Materials’ That Build Themselves, Science28 MARCH 2014 1421.<br /> | |
- | + | [2]XING Yan-ping, WANG Yu, YANG Feng, LEILian-cheng, Pathogenicity of Escherichia coli Curli Fibers, Journal of Hebei Normal University of Science & Technology Vo.l 25 No. 1March, 2011.<br /> | |
- | + | [3]ZHU Jun, WANG Jian-Ye, ZHU Guo-Qiang, Biogenesis and Pathogenicity of Escherichia coli Curli Fibers, LETTERS IN BIOTECHNOLOGY , Vol.20 No.1 Jan.2009</span></td> | |
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Revision as of 03:21, 15 October 2014
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