Team:Tianjin/Safety
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<td><span class="STYLE69"><a href="#part1">The safety of lab</a></span></td> | <td><span class="STYLE69"><a href="#part1">The safety of lab</a></span></td> | ||
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- | <td height="2547" class="STYLE33"><span class="STYLE48">Alarm bells</span><br /> | + | <td height="2547" bgcolor="#993300" class="STYLE33"><span class="STYLE48">Alarm bells</span><br /> |
According to the Ministry of Education “2008-2009 General Undergraduate Colleges Laboratory Information Statistics”, there are 26479 laboratories in 1129 total regular undergraduate colleges in China, laboratory area 2 6.015 million m2. With so many laboratories, safety accidents have occured from time to time. In 2009, a university teacher of the department of chemistry mistakenly accessed CO gas into 307 lab, which should have been accessed to 211 lab. A woman doctor died because of this fault; In 2010, students and teachers of a university in northeast of China used goats without being checked in their experiments, which lead 27 students and 1 teacher were diagnosed as infected with brucellosis; In 2013, a postgraduate student named Huang Yang from Fudan University died of poisoning in Shanghai Zhongshan Hospital. According to the report of the police's investigation, a toxic chemical compound was found in the drinking water dispenser in Huang's dormitory room, and this toxic chemical compoud is taken out of a laboratory.<br /> | According to the Ministry of Education “2008-2009 General Undergraduate Colleges Laboratory Information Statistics”, there are 26479 laboratories in 1129 total regular undergraduate colleges in China, laboratory area 2 6.015 million m2. With so many laboratories, safety accidents have occured from time to time. In 2009, a university teacher of the department of chemistry mistakenly accessed CO gas into 307 lab, which should have been accessed to 211 lab. A woman doctor died because of this fault; In 2010, students and teachers of a university in northeast of China used goats without being checked in their experiments, which lead 27 students and 1 teacher were diagnosed as infected with brucellosis; In 2013, a postgraduate student named Huang Yang from Fudan University died of poisoning in Shanghai Zhongshan Hospital. According to the report of the police's investigation, a toxic chemical compound was found in the drinking water dispenser in Huang's dormitory room, and this toxic chemical compoud is taken out of a laboratory.<br /> | ||
<img src="https://static.igem.org/mediawiki/2014/b/b4/Tianjin-safety.png" width="400" height="264" hspace="150" align="middle" /><br /> | <img src="https://static.igem.org/mediawiki/2014/b/b4/Tianjin-safety.png" width="400" height="264" hspace="150" align="middle" /><br /> | ||
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<strong>——What is happening to our lab?</strong></span></span><span class="STYLE71"><strong></strong></span><strong><br /> | <strong>——What is happening to our lab?</strong></span></span><span class="STYLE71"><strong></strong></span><strong><br /> | ||
</strong> Laboratory safety awareness is the "Achilles heel" to our lab. Too much facts tell us that most accidents are caused by negligence of researchers. Do experiments without wearing gloves or lab coats, pile up clutter at random in the laboratory, or eat pineapples in the laboratory during experimental clearances. Now ask yourself, have these phenomenon happened to you or around you on earth before?<br /> | </strong> Laboratory safety awareness is the "Achilles heel" to our lab. Too much facts tell us that most accidents are caused by negligence of researchers. Do experiments without wearing gloves or lab coats, pile up clutter at random in the laboratory, or eat pineapples in the laboratory during experimental clearances. Now ask yourself, have these phenomenon happened to you or around you on earth before?<br /> | ||
- | <img src="https://static.igem.org/mediawiki/2014/1/15/Tianjin-safety2.png" width="400" height="299" hspace="150" align=" | + | <img src="https://static.igem.org/mediawiki/2014/1/15/Tianjin-safety2.png" width="400" height="299" hspace="150" align="middle" /><br clear="all" /> |
<span class="STYLE72"><span class="STYLE71"><strong>preventive measures </strong><br /> | <span class="STYLE72"><span class="STYLE71"><strong>preventive measures </strong><br /> | ||
<strong>——How to avoid the occurrence of laboratory accidents?</strong></span></span><span class="STYLE71"><strong></strong></span><strong><br /> | <strong>——How to avoid the occurrence of laboratory accidents?</strong></span></span><span class="STYLE71"><strong></strong></span><strong><br /> | ||
</strong> Laboratory safety issues can not be ignored. Tianjin University started the “Lab-Safety Month of Tianjin University”under the advocation of our IGEM team since 2013. A number of activities were held to enhance students’ safety awareness. Here, we launched the initiative that everyone pay more attention to laboratory safety, starting from things around us and from ourselves.<br /> | </strong> Laboratory safety issues can not be ignored. Tianjin University started the “Lab-Safety Month of Tianjin University”under the advocation of our IGEM team since 2013. A number of activities were held to enhance students’ safety awareness. Here, we launched the initiative that everyone pay more attention to laboratory safety, starting from things around us and from ourselves.<br /> | ||
- | <img src="https://static.igem.org/mediawiki/2014/f/f2/Tianjin-safety3.png" width="400" height="299" hspace="150" /> <br clear="all" /> | + | <img src="https://static.igem.org/mediawiki/2014/f/f2/Tianjin-safety3.png" width="400" height="299" hspace="150" align="middle" /> <br clear="all" /> |
<span class="STYLE72"><strong>Safety Tips:</strong></span><br /> | <span class="STYLE72"><strong>Safety Tips:</strong></span><br /> | ||
1. Always wear appropriate personal protective equipment. Feet and legs should be covered; sandals and open-toed shoes should not be worn in laboratories. Wear appropriate gloves while handling infectious or toxic materials and animals. Do not wear lab coats, gloves or other personal protective equipment outside the laboratory. Change gloves when contaminated, and dispose of used gloves with other contaminated laboratory waste.<br /> | 1. Always wear appropriate personal protective equipment. Feet and legs should be covered; sandals and open-toed shoes should not be worn in laboratories. Wear appropriate gloves while handling infectious or toxic materials and animals. Do not wear lab coats, gloves or other personal protective equipment outside the laboratory. Change gloves when contaminated, and dispose of used gloves with other contaminated laboratory waste.<br /> | ||
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<td><p class="STYLE33"> Curli fiber expressed by the bacterium Escherichia coli is a bacterial form of amyloid. Amyloid fibers are associated with a variety of disease states, including prion diseases and systemic amyloidosis. Curli fiber has a strong adhesive power,?? can combine with the surface material of many organisms, including fiber mucin, laminin, plasminogen and so on. Vitro and in vivo tests showed that those bacteria? that be able to produce curli produce more virulence than bacteria that don’t produce curli, including adhesion, planting and invasion capacity of the host cell. E. Coli can produce curli fiber in its mammalian host, which may bring related <a href="C://Users/lihuize/AppData/Local/Yodao/DeskDict/frame/20140810194504/javascript:void(0);"></a> inflammation like sepsis to its hosts. Luckily, the synthetic curli fiber in our project is used outside of our body, so it will not bring such safety problem. Besides, in the intact bacterium, the expression of curli requires the concerted action of several gene products. Understanding how curli are assembled may help in our understanding of pathological amyloids in human disease.<br /> | <td><p class="STYLE33"> Curli fiber expressed by the bacterium Escherichia coli is a bacterial form of amyloid. Amyloid fibers are associated with a variety of disease states, including prion diseases and systemic amyloidosis. Curli fiber has a strong adhesive power,?? can combine with the surface material of many organisms, including fiber mucin, laminin, plasminogen and so on. Vitro and in vivo tests showed that those bacteria? that be able to produce curli produce more virulence than bacteria that don’t produce curli, including adhesion, planting and invasion capacity of the host cell. E. Coli can produce curli fiber in its mammalian host, which may bring related <a href="C://Users/lihuize/AppData/Local/Yodao/DeskDict/frame/20140810194504/javascript:void(0);"></a> inflammation like sepsis to its hosts. Luckily, the synthetic curli fiber in our project is used outside of our body, so it will not bring such safety problem. Besides, in the intact bacterium, the expression of curli requires the concerted action of several gene products. Understanding how curli are assembled may help in our understanding of pathological amyloids in human disease.<br /> | ||
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