Team:Paris Bettencourt/Project/Foot Odor
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<h6>Introduction</h6><br> | <h6>Introduction</h6><br> | ||
<p class=text1>The aim of this sub-project is to produce Bacillus subtilis, which lacks the capability of producing isovaleric acid and hence the bad foot odor.</p> | <p class=text1>The aim of this sub-project is to produce Bacillus subtilis, which lacks the capability of producing isovaleric acid and hence the bad foot odor.</p> | ||
</div> | </div> | ||
<div id=part2> | <div id=part2> | ||
- | <p class=text2></p> | + | <p class=text2><img src="https://static.igem.org/mediawiki/2014/b/b1/Footfigure1PB.png">Fig1</p> |
<h6>Motivation</h6><br> | <h6>Motivation</h6><br> | ||
<p class=text1>We hypothesize that bad foot odor could be eradicated by perturbing the Leucine degradation pathway.</br> | <p class=text1>We hypothesize that bad foot odor could be eradicated by perturbing the Leucine degradation pathway.</br> |
Revision as of 15:18, 14 October 2014
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BACKGROUND Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
AIMS Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
RESULTS Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
BIOBRICKS Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
Introduction | Aims | Part3 | Part4 | Part5 |
Introduction
The aim of this sub-project is to produce Bacillus subtilis, which lacks the capability of producing isovaleric acid and hence the bad foot odor.
Fig1
Motivation
We hypothesize that bad foot odor could be eradicated by perturbing the Leucine degradation pathway. We choose leucine dehydrogenase and iso-valeryl coA to perturb the leucine degradation pathway. Our goal here is to have two different strategies to inhibit isovaleric acid production. our first strategy focus on producing B.subtilis which will not be capable of producing leucine, so that it has to utilize all the leucine it could get from the sweat for its own survival rather than the production of isovaleric acid. Our second strategy focus on developing B.subtilis strain, which will be capable of producing leucine but not isovaleric acid.
Aims
The aim of this sub-project is to produce Bacillus subtilis, which lacks the capability of producing isovaleric acid and hence the bad foot odor.
Fig2
Fig3
Results
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