Team:Goettingen/project overview/fungal infections

From 2014.igem.org

(Difference between revisions)
m
m
 
(56 intermediate revisions not shown)
Line 1: Line 1:
{{:Team:Goettingen/header}}
{{:Team:Goettingen/header}}
-
 
+
{{:Team:Goettingen/projectLP}}
<html>
<html>
<body>
<body>
 +
<script>
 +
      window.fbAsyncInit = function() {
 +
        FB.init({
 +
          appId      : 'fb-like',
 +
          xfbml      : true,
 +
          version    : 'v2.0'
 +
        });
 +
      };
 +
 +
      (function(d, s, id){
 +
        var js, fjs = d.getElementsByTagName(s)[0];
 +
        if (d.getElementById(id)) {return;}
 +
        js = d.createElement(s); js.id = id;
 +
        js.src = "//connect.facebook.net/en_US/sdk.js";
 +
        fjs.parentNode.insertBefore(js, fjs);
 +
      }(document, 'script', 'facebook-jssdk'));
 +
    </script>
 +
<script src="http://d3js.org/d3.v3.min.js"></script>
<script src="http://d3js.org/d3.v3.min.js"></script>
  <script src="http://d3js.org/topojson.v1.min.js"></script>
  <script src="http://d3js.org/topojson.v1.min.js"></script>
Line 9: Line 27:
<!-- main part of the subpage -->
<!-- main part of the subpage -->
<div id="subpage">     
<div id="subpage">     
-
<!-- left column-->
 
-
<div class="leftpart">
 
-
        <h3>Project</h3>
 
-
        <ul>
 
-
        <li><a href="https://2014.igem.org/Team:Goettingen/project_overview">Background</a></li>
 
-
<ul>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview">The global burden of fungal infections</a></li>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/fungal_infections">Fungal infections</a></li>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/current_tools">Current diagnostic tools</a></li></ul>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/project">Our project!</a></li>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/perspectives">Further perspectives</a></li>
 
-
<ul>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/diganosis">Diagnosis</a></li>
 
-
<li><a href="https://2014.igem.org/Team:Goettingen/project_overview/therapeutics">Therapeutics</a></li></ul>
 
-
 
-
 
-
 
-
 
-
       
 
-
        </ul>
 
-
    </div>
 
-
<!-- end of left column-->
 
<!-- right column-->
<!-- right column-->
-
<div class="rightpart" id="rpart1">
+
<div class="proRP" id="rpart1">
-
<div id="goenext"><a href="https://2014.igem.org/Team:Goettingen/project_overview"><img src='https://static.igem.org/mediawiki/2014/3/32/Goettingen2014-previous.png' width='50px'></a> 2/7 <a href="https://2014.igem.org/Team:Goettingen/project_overview/current_tools"><img src='https://static.igem.org/mediawiki/2014/e/ea/Goettingen2014-next.png' width='50px'></a></div><br />
+
<div id="goenext"><a id="prev"><img id="pButton"></a> 3/15 <a id="next"><img id="nButton"></a></div>
-
       <h2 id="fungal_inf">Fungal infections and current diagnostic tools</h2>
+
      <h1>Background</h1><br /><br />
 +
       <h2>Fungal infections</h2><br />
<p>The most common fungal infections are superficial skin, nails and mucosal infections, which are caused in most cases by fungi of the genus <i>Candida</i>. These infections are usually not life threatening and have such common manifestations as athlete's foot and vulvovaginal candidiasis.</p>
<p>The most common fungal infections are superficial skin, nails and mucosal infections, which are caused in most cases by fungi of the genus <i>Candida</i>. These infections are usually not life threatening and have such common manifestations as athlete's foot and vulvovaginal candidiasis.</p>
Line 41: Line 38:
<p>According to Brown, <i>et al</i>., (2012), more than 90% of the reported deaths caused by fungi are associated with species from four genera: <i>Cryptococcus</i>, <i>Candida</i>, <i>Aspergillus</i> and <i>Pneumocystis</i>, but epidemiological data for fungal infections is poor, as these infections are often misdiagnosed and there is a lack of accurate data from the developing world.</p><br />
<p>According to Brown, <i>et al</i>., (2012), more than 90% of the reported deaths caused by fungi are associated with species from four genera: <i>Cryptococcus</i>, <i>Candida</i>, <i>Aspergillus</i> and <i>Pneumocystis</i>, but epidemiological data for fungal infections is poor, as these infections are often misdiagnosed and there is a lack of accurate data from the developing world.</p><br />
-
<h3>Endemic dimorphic fungosis</h3><br />
+
<h3>Endemic dimorphic mycoses</h3><br />
-
<p> The following map is an adaptiation of the information presented in Brown, <i>et al</i>., (2012), where the authors make some comments regarding the quality of that information: 1) the data is extrapolated from a few and geographically localized studies and 2) accurate data is lacking from the developing world and the calculations may underestimate the true values of the presented statistics.</p><br />
+
<p> The following map is an adaptation of the information presented in Brown, <i>et al</i>., (2012), where the authors make some comments regarding the quality of that information: <br /> <br />1) The data is extrapolated from a few and geographically localized studies <br /><br /> 2) accurate data is lacking from the developing world and the calculations may underestimate the true values of the presented statistics.</p><br />
 +
<p><center><b>Hover your pointer over the colored circles to see the data</b></center></p><br />
 +
 
<div id="container1" style="position: relative; width: 650px; height: 350px;"></div>
<div id="container1" style="position: relative; width: 650px; height: 350px;"></div>
        
        
Line 77: Line 76:
{name: '<b>Disease:</b> Blastomycosis<br><b>Pathogen:</b><i> Blastomyces dermatitidis</i><br><b>Region:</b> Midwestern and Atlantic United States<br><b>Est. life-threatening infections per year</b> ~3,000', latitude: 37, longitude: -80, radius: 8, fillKey: 'gt51'},
{name: '<b>Disease:</b> Blastomycosis<br><b>Pathogen:</b><i> Blastomyces dermatitidis</i><br><b>Region:</b> Midwestern and Atlantic United States<br><b>Est. life-threatening infections per year</b> ~3,000', latitude: 37, longitude: -80, radius: 8, fillKey: 'gt51'},
{name: '<b>Disease:</b> Paracoccidioidomycosis<br><b>Pathogen:</b><i> Paracoccidioides brasiliensis</i><br><b>Region:</b> Brazil<br><b>Est. life-threatening infections per year</b>: ~4,000', latitude: -15.7833, longitude: -47.8667, radius: 8, fillKey: 'gt50'},
{name: '<b>Disease:</b> Paracoccidioidomycosis<br><b>Pathogen:</b><i> Paracoccidioides brasiliensis</i><br><b>Region:</b> Brazil<br><b>Est. life-threatening infections per year</b>: ~4,000', latitude: -15.7833, longitude: -47.8667, radius: 8, fillKey: 'gt50'},
-
 
     ], {
     ], {
Line 83: Line 81:
         return "<div class='hoverinfo'><p>"+ data.name + "</p></div>";
         return "<div class='hoverinfo'><p>"+ data.name + "</p></div>";
       },
       },
-
 
     });
     });
Line 91: Line 88:
     </script>
     </script>
-
<br />
+
<br /><br />
-
<h3>Invasive fungoses</h3><br />
+
<h3>Opportunistic invasive mycoses</h3><br />
 +
<p>Opportunistic mycoses affect those patients with a compromised immune system, such as AIDS patients and patients taking immmuno-suppressants, particularly those patients that were intervened with a solid transplantation. The following interactive graphic is also an adaption of the information presented in Brown <i>et al</i>., (2012).</p><br />
 +
<p>From top to bottom, the data on the upper-right corner is the following: 1) Disease name, 2) The causative organism  3) Mortality rates (% in infected populations) and 4) Estimated number of life threatening infections per year worldwide.</p><br />
 +
<p><center><b>Hover your pointer over the colored circles to see the data</b></center></p><br />
-
<div id="container2" style="position: relative; width: 650px; height: 350px;">
+
 
 +
<div id="container2" style="position: relative; width: 650px; height: 400px;">
<script>
<script>
-
var diameter = 700,
+
var diameter = 600,
     format = d3.format(",d"),
     format = d3.format(",d"),
     color = d3.scale.category20c();
     color = d3.scale.category20c();
Line 130: Line 131:
   .attr("y", 80)
   .attr("y", 80)
   .style("font-size", "32px")
   .style("font-size", "32px")
-
   .style("text-anchor", "left")
+
   .style("text-align", "right")
   .text("Disease");
   .text("Disease");
Line 138: Line 139:
   .attr("x", 400)
   .attr("x", 400)
   .attr("y", 110)
   .attr("y", 110)
-
  .style("text-anchor", "left")
+
.style("font-size", "16px")  
-
.style("font-size", "12px")
+
  .style("text-align", "right")
   .text("Organism");
   .text("Organism");
Line 147: Line 148:
   .attr("x", 400)
   .attr("x", 400)
   .attr("y", 170)
   .attr("y", 170)
-
   .style("text-anchor", "left")
+
   .style("text-align", "right")
-
.style("font-size", "12px")
+
.style("font-size", "14px")
-
   .text("Est. life threatening infections per year worldwide");
+
   .text("Est. life-threatening infections/year worldwide");
    
    
// mortality rates
// mortality rates
Line 156: Line 157:
   .attr("x", 400)
   .attr("x", 400)
   .attr("y", 140)
   .attr("y", 140)
-
  .style("text-anchor", "left")
+
    .style("text-align", "right")
-
.style("font-size", "12px")
+
.style("font-size", "16px")
   .text("Mortality rates (% in infected populations)");
   .text("Mortality rates (% in infected populations)");
Line 181: Line 182:
       .style("fill", d3.rgb(203,234,247))
       .style("fill", d3.rgb(203,234,247))
.on("mouseover", function(d) {
.on("mouseover", function(d) {
-
      d3.select("#disease").text(d.className);
+
 
 +
d3.select("#disease").text(d.className);
       d3.select("#organism").text(d.organism);
       d3.select("#organism").text(d.organism);
       d3.select("#lifeThreat").text(d.lifeThreat);
       d3.select("#lifeThreat").text(d.lifeThreat);
Line 214: Line 216:
d3.select(self.frameElement).style("height", diameter + "px");
d3.select(self.frameElement).style("height", diameter + "px");
-
</script></div>
+
</script></div><br /><br />
 +
<hr>
 +
<br /><br />
 +
 
 +
<h2>References</h2><br />
 +
<ol>
 +
<li>1. Brown <i>et al</i>., (2012), Hidden Killers: Human Fungal Infections, <i>Sci Transl Med</i>, Vol. 4, Issue 165.</li>
 +
</ol>
 +
<br /><br />
 +
        <div id="goenext"><a id="prev"><img id="pButton"></a> 3/15 <a id="next"><img id="nButton"></a></div>
 +
      <br />
 +
 
 +
<script>
 +
var curl = document.URL;
 +
$( '#fb-like' ).attr('data-href', curl);
 +
</script>
 +
 
     </div>
     </div>
 +
 +
<!-- end of right column-->
<!-- end of right column-->
</div>
</div>
Line 222: Line 242:
</div>
</div>
 +
 +
 +
<script>$(document).keydown(function(e) {
 +
    switch(e.which) {
 +
        case 37: // left
 +
window.location = url2;
 +
        break;
 +
   
 +
 +
        case 39: // right
 +
console.log("right");
 +
window.location = url4;
 +
        break;
 +
 +
     
 +
 +
        default: return; // exit this handler for other keys
 +
    }
 +
    e.preventDefault(); // prevent the default action (scroll / move caret)
 +
});</script>
 +
<script>
 +
$( "[id=next]" ).attr("href", url4);
 +
$( "[id=prev]" ).attr("href", url2);
 +
$( "[id=nButton]" ).attr("src", nextButton).attr("width", "40");
 +
$( "[id=pButton]" ).attr("src", prevButton).attr("width", "40");
 +
</script>
 +
</body>
</body>
</html>
</html>

Latest revision as of 11:08, 2 October 2014

Project

3/15

Background



Fungal infections


The most common fungal infections are superficial skin, nails and mucosal infections, which are caused in most cases by fungi of the genus Candida. These infections are usually not life threatening and have such common manifestations as athlete's foot and vulvovaginal candidiasis.


Invasive fungal infections, on the other hand, have unacceptably high mortality rates. Patients with a compromised immune system -such as AIDS patients and post-transplantation patients taking immunosupresants- are at special risk as they don't have the usual barriers that prevent invasive infections in healthy individuals.


According to Brown, et al., (2012), more than 90% of the reported deaths caused by fungi are associated with species from four genera: Cryptococcus, Candida, Aspergillus and Pneumocystis, but epidemiological data for fungal infections is poor, as these infections are often misdiagnosed and there is a lack of accurate data from the developing world.


Endemic dimorphic mycoses


The following map is an adaptation of the information presented in Brown, et al., (2012), where the authors make some comments regarding the quality of that information:

1) The data is extrapolated from a few and geographically localized studies

2) accurate data is lacking from the developing world and the calculations may underestimate the true values of the presented statistics.


Hover your pointer over the colored circles to see the data




Opportunistic invasive mycoses


Opportunistic mycoses affect those patients with a compromised immune system, such as AIDS patients and patients taking immmuno-suppressants, particularly those patients that were intervened with a solid transplantation. The following interactive graphic is also an adaption of the information presented in Brown et al., (2012).


From top to bottom, the data on the upper-right corner is the following: 1) Disease name, 2) The causative organism 3) Mortality rates (% in infected populations) and 4) Estimated number of life threatening infections per year worldwide.


Hover your pointer over the colored circles to see the data






References


  1. 1. Brown et al., (2012), Hidden Killers: Human Fungal Infections, Sci Transl Med, Vol. 4, Issue 165.


3/15

Retrieved from "http://2014.igem.org/Team:Goettingen/project_overview/fungal_infections"