Team:UFAM Brazil/Modeling

From 2014.igem.org

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The Hg²+ ions uptake and entrance from the cell exterior to the interior system and its subsequent reduction to Hg<sup>0</sup> species is a complex process that has several steps for its realization. This procedure aims to transform the mercury ion in a volatile element (Hg<sup>0</sup>), able to passively diffuse through the membranes to the cell exterior.  
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The Hg<sup>2+</sup> ions uptake and entrance from the cell exterior to the interior system and its subsequent reduction to Hg<sup>0</sup> species is a complex process that has several steps for its realization. This procedure aims to transform the mercury ion in a volatile element (Hg<sup>0</sup>), able to passively diffuse through the membranes to the cell exterior.  
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According to Figure 1, the uptake and reduction system operates basically with merP, merT, merC, merF and merA proteins, being the first a periplasmic protein that binds to mercury ion for carrying to one of its transporters (merT, merC or merF), which are located in the inner membrane, and release Hg²+ inside the cells. Then, Hg²+ undergoes the merA enzyme action, which can reduce Hg²+ to Hg<sup>0</sup>, thereby enables its passive exist by membrane.
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According to Figure 1, the uptake and reduction system operates basically with merP, merT, merC, merF and merA proteins, being the first a periplasmic protein that binds to mercury ion for carrying to one of its transporters (merT, merC or merF), which are located in the inner membrane, and release Hg²+ inside the cells. Then, Hg<sup>2+</sup> undergoes the merA enzyme action, which can reduce Hg<sup>2+</sup> to Hg<sup>0</sup>, thereby enables its passive exist by membrane.
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Revision as of 17:32, 29 September 2014

The Hg2+ ions uptake and entrance from the cell exterior to the interior system and its subsequent reduction to Hg0 species is a complex process that has several steps for its realization. This procedure aims to transform the mercury ion in a volatile element (Hg0), able to passively diffuse through the membranes to the cell exterior.

According to Figure 1, the uptake and reduction system operates basically with merP, merT, merC, merF and merA proteins, being the first a periplasmic protein that binds to mercury ion for carrying to one of its transporters (merT, merC or merF), which are located in the inner membrane, and release Hg²+ inside the cells. Then, Hg2+ undergoes the merA enzyme action, which can reduce Hg2+ to Hg0, thereby enables its passive exist by membrane.