Team:Saarland

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== Project Rufus or the Force of the Naked Mole- Rat ==

The iGEM- Team Saarland embraces human- and molecular biology and biophysics. We are 10 bachelor-/master students trained in handling biotechnological questions such as the planned identification, purification, biological characterization and technological production of bacteria- born substances. Our aim is to employ a simple soil bacterium as medium for the first ever production of a special hyaluronic acid that was recently identified in the naked mole- rat (Heterocephalus glaber). Fibroblasts of the naked mole- rat were found to secrete a high- molecular- mass hyaluronic acid that is 5 times larger than the human or mouse hyaluronic acid. This phenomenon is supposed to cause the cancer resistance in the species of Heterocephalus glaber. Within the project run- time the special hyaluronic acid will be produced, purified and tested in its inhibitory effects on carcinogenesis in selected human cancer cell lines. These biological tests will be run on physiological and molecular level in cell culture.


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