Team:UT-Tokyo

From 2014.igem.org

(Difference between revisions)
Line 1: Line 1:
-
[[Counter]]
+
[[/Counter]]
{{CSS/UT-Tokyo}}
{{CSS/UT-Tokyo}}
<html>
<html>

Revision as of 07:02, 15 September 2014

/Counter

Project Description

In the field of synthetic biology, Genetic memory devices have been constructed and applied widely from Biocomputing to biomedical technologies as a crucial component. Such memory devices include a cellular counter; a fundamental device which memorizes the number of induction events. Recent efforts have resulted in a cellular counter that can count up to three events. However, this counter cannot be reset to its initial state. Here, we propose a resettable cellular counter called “sigma recounter”. This counter utilizes the regulation system of sigma factor and anti-sigma factor as the key of its resetting mechanism. In this system a set of sigma factors are designed to update and maintain a count that responds to each inducted event. By the other stimulus, the system initiates a genetic circuit that can express a suitable set of anti-sigma factors and erases the existing memory, which will enable our device to restart the count from any state.

Our Team


Address

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654 Japan