Team:ULB-Brussels

From 2014.igem.org

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<section style="text-align: justify; margin: 25px"><p>This year, the <i>Université Libre de Bruxelles</i> competes again in the International Genetically Engineered Machines contest, a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.</p>
<section style="text-align: justify; margin: 25px"><p>This year, the <i>Université Libre de Bruxelles</i> competes again in the International Genetically Engineered Machines contest, a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.</p>
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<p>Our team will present a new biological system aiming to fight against the emergence of unproductive cell sub-populations in bioreactors by coupling recombinant protein production with an essential protein, thus addicting cells to production. We hope this idea will significantly increase production in fermenters and bioreactors. For further information, please see the page dedicated to the project.</p>
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<p>Our aim is to enhance recombinant protein production in bioreactors by making microorganisms addict to the production of a protein of interest (POI). We built MightyColi, a recombinant Escherichia Coli expressing a toxin and a POI. This POI will be on the same open reading frame than an antoxin, a protein able to neutralize the effects of the toxin. Stressed subpopulations might not express the POI (and thus the antitoxin) to a sufficient level, allowing the toxin to kill unproductive cells. Our work will consist on building and modelling this system. </p></section>
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<p>On this website, you can also find all the details about our sponsors and the evolution of the project. Feel free to browse.</p></section>
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Revision as of 10:15, 1 September 2014

$~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\MyColi}{{\small Mighty\hspace{0.12cm}Coli}} \newcommand{\Stabi}{\small Stabi}$ $\newcommand{\EColi}{\small E.coli} \newcommand{\SCere}{\small S.cerevisae}\\[0cm] ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\PI}{\small PI}$ $\newcommand{\Igo}{\Large\mathcal{I}} \newcommand{\Tgo}{\Large\mathcal{T}} \newcommand{\Ogo}{\Large\mathcal{O}} ~$ Example of a hierarchical menu in CSS

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- Université Libre de Bruxelles -


Welcome to our website


This year, the Université Libre de Bruxelles competes again in the International Genetically Engineered Machines contest, a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.

Our aim is to enhance recombinant protein production in bioreactors by making microorganisms addict to the production of a protein of interest (POI). We built MightyColi, a recombinant Escherichia Coli expressing a toxin and a POI. This POI will be on the same open reading frame than an antoxin, a protein able to neutralize the effects of the toxin. Stressed subpopulations might not express the POI (and thus the antitoxin) to a sufficient level, allowing the toxin to kill unproductive cells. Our work will consist on building and modelling this system.



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