Team:Tufts/outreach
From 2014.igem.org
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- | <center> <h3> A Primer in Biological Research at Tufts </h3> </center> | + | <center> <h3> Lecture Series: A Primer in Biological Research at Tufts </h3> </center> |
<center> Fall 2014 </center> <br> | <center> Fall 2014 </center> <br> | ||
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prepared to pursue undergraduate research in a professor’s lab or as a member of the Tufts | prepared to pursue undergraduate research in a professor’s lab or as a member of the Tufts | ||
Synthetic Biology team. </p> | Synthetic Biology team. </p> | ||
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<td> <center> <b> Speaker </b></center></td> | <td> <center> <b> Speaker </b></center></td> | ||
<td> <center> <b> Readings </b> </center> </td> | <td> <center> <b> Readings </b> </center> </td> | ||
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<a href = "http://www.readcube.com/articles/10.1038/nature11927"> 3. A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity </a> | <a href = "http://www.readcube.com/articles/10.1038/nature11927"> 3. A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity </a> | ||
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<td> Bacteriophage Conference </td> | <td> Bacteriophage Conference </td> | ||
<td> None</td> | <td> None</td> | ||
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<a href = "http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1236/pdf" > 3. Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities </a> <br> | <a href = "http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1236/pdf" > 3. Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities </a> <br> | ||
<a href = "http://www.futuremedicine.com/doi/pdfplus/10.2217/rme.11.69" > 4. The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology and cancer </a> | <a href = "http://www.futuremedicine.com/doi/pdfplus/10.2217/rme.11.69" > 4. The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology and cancer </a> | ||
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<a href = "http://www.pnas.org/content/109/48/19584.abstract" > 3. Implantable, multifunctional, bioresorbable optics </a> <br> | <a href = "http://www.pnas.org/content/109/48/19584.abstract" > 3. Implantable, multifunctional, bioresorbable optics </a> <br> | ||
<a href = "http://www.sciencemag.org/content/329/5991/528.full" > 4. Optional: New Opportunities for an Ancient Material </a> <br> | <a href = "http://www.sciencemag.org/content/329/5991/528.full" > 4. Optional: New Opportunities for an Ancient Material </a> <br> | ||
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<a href = "http://onlinelibrary.wiley.com/doi/10.1002/cbic.200700765/pdf"> 2. Evolution in Reverse: Engineering a d-Xylose-Specific Xylose Reductase </a> | <a href = "http://onlinelibrary.wiley.com/doi/10.1002/cbic.200700765/pdf"> 2. Evolution in Reverse: Engineering a d-Xylose-Specific Xylose Reductase </a> | ||
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<td> <a href = "http://www.cs.tufts.edu/~soha/">Soha Hassoun </a> and <a href = "http://www.cs.tufts.edu/~hescott/">Benjamin Hescott</a> </td> | <td> <a href = "http://www.cs.tufts.edu/~soha/">Soha Hassoun </a> and <a href = "http://www.cs.tufts.edu/~hescott/">Benjamin Hescott</a> </td> | ||
<td> TBD </td> | <td> TBD </td> | ||
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<td> <a href = "http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Jonathan-Garlick-Profile" > Jonathan Garlick </a> </td> | <td> <a href = "http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Jonathan-Garlick-Profile" > Jonathan Garlick </a> </td> | ||
<td> None </td> | <td> None </td> | ||
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<td> <a href = "http://chem.tufts.edu/faculty/walt/" >David Walt </a> </td> | <td> <a href = "http://chem.tufts.edu/faculty/walt/" >David Walt </a> </td> | ||
<td> None </td> | <td> None </td> | ||
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<a href = "http://onlinelibrary.wiley.com/doi/10.1002/cbic.201200175/pdf" > 3. Peptide Bicycles that Inhibit the Grb2 SH2 Domain </a> | <a href = "http://onlinelibrary.wiley.com/doi/10.1002/cbic.201200175/pdf" > 3. Peptide Bicycles that Inhibit the Grb2 SH2 Domain </a> | ||
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<td> Final Presentations </td> | <td> Final Presentations </td> | ||
<td> None </td> | <td> None </td> | ||
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- | <h4>Intellectual Goals | + | <h4>Intellectual Goals </h4> |
<p style="font-size:15px"> | <p style="font-size:15px"> | ||
To impart familiarity and a thorough understanding of the components involved in the research, | To impart familiarity and a thorough understanding of the components involved in the research, | ||
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- Human practices <br> | - Human practices <br> | ||
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- | <h4>Recommended Readings | + | <h4>Recommended Readings </h4> |
<p style="font-size:15px"> | <p style="font-size:15px"> | ||
Required readings are listed in the schedule. The below are additional readings for further knowledge on the topic of synthetic biology. <br> | Required readings are listed in the schedule. The below are additional readings for further knowledge on the topic of synthetic biology. <br> | ||
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Science, 1252-1254. <br> | Science, 1252-1254. <br> | ||
10) Steven, B., & Sismour, M. (2005). Synthetic biology. Nature Reviews Genetics, 533-543. <br><br> | 10) Steven, B., & Sismour, M. (2005). Synthetic biology. Nature Reviews Genetics, 533-543. <br><br> | ||
- | <h4> Student Involvement | + | <h4> Student Involvement </h4> |
<p style="font-size:15px"> | <p style="font-size:15px"> | ||
Before guest lectures, the class will receive papers written by the visiting lecturer. A one- | Before guest lectures, the class will receive papers written by the visiting lecturer. A one- | ||
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required for the 4th, 7th, and 9th weeks of the course to ensure all students are progressing at a | required for the 4th, 7th, and 9th weeks of the course to ensure all students are progressing at a | ||
sufficient pace. <br><br> | sufficient pace. <br><br> | ||
- | <h4> Final Project Description | + | <h4> Final Project Description </h4> |
<p style="font-size:15px"> | <p style="font-size:15px"> | ||
All semester projects include the following: <br> | All semester projects include the following: <br> | ||
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Latest revision as of 23:02, 17 October 2014
Lecture Series: A Primer in Biological Research at Tufts
Biology and the life sciences have experienced extensive innovations over the last half century. Researchers at Tufts have been consistent contributors to these major advancements making their work pertinent teaching material for students interested in pursuing research opportunities. In this course, undergraduates will not only be able to explore the landscape of biological research performed at Tufts, but engage in discussions with the faculty behind it. Over the course of the semester, the students will become acquainted with various research publications by creating presentations, drafting proposals, and discussing the research with faculty and peers. The course will culminate in group proposals in which the students develop a potential research endeavor based on the principles examined throughout the course. Students will have the opportunity to have these proposals funded with the help of the Tufts Synthetic Biology team. The goal of the Tufts Synthetic Biology team has been to establish an undergraduate team of researchers who will work closely with select faculty to take part in an annual competition, learn about research on campus, discuss bioethics, and learn how to write a research proposal. We believe the best way to intellectually prime and train undergraduates who want to take part in this highly independent research project is through a class which exposes them not only to the technical aspects of the molecular biology techniques involved but also to the administrative necessities of running an independent lab. Students taking this course will be prepared to pursue undergraduate research in a professor’s lab or as a member of the Tufts Synthetic Biology team.
Speaker Schedule
Intellectual Goals
To impart familiarity and a thorough understanding of the components involved in the research,
design, development, and experimentation associated with the life sciences, for real
world experience and application. Students, particularly underclassman, taking the course will
gain insight into the landscape of research at Tufts so that they may become involved more
rapidly.
Specific Topics:
- Overview research in Life Sciences at Tufts
- Fundamental molecular biology techniques
- Current methods for genomic modification
- Ethical considerations of research
- Human practices
Recommended Readings
Required readings are listed in the schedule. The below are additional readings for further knowledge on the topic of synthetic biology.
1) Geoff Baldwin, Kitney Richard I, Travis Bayer, Freemont Paul S, Tom Ellis, Karen
Polizzi, Guy-Bary Stan. Synthetic Biology: A Primer
2) Bohannon, J. (2011). The Life Hacker. Science, 1236-1237.
3) Brent, E., Singh, R., & Winters, P. (2011). Synthetic Biology: Regulating Industry Uses
of New Biotechnologies. Science, 1254-1256.
5) Church, G. (2012). Regenesis: How Synthetic Biology Will Reinvent Nature and
Ourselves. Basic Books.
6) David, G. (2009). The Machinery of Life. Copernicus.
7) Enriquez, J. (2005). As the Future Catches You. Crown Business.
8) Khalil, A., & Collins, J. (2010). Synthetic biology: Applications Come of Age. Nature,
367-379.
9) Schwille, P. (2011). Bottom-Up Synthetic Biology: Engineering in a Tinkerer’s World.
Science, 1252-1254.
10) Steven, B., & Sismour, M. (2005). Synthetic biology. Nature Reviews Genetics, 533-543.
Student Involvement
Before guest lectures, the class will receive papers written by the visiting lecturer. A one-
page summary and reflection of the publication is to be completed for the following class
during which discussion of the article will occur. All students must also be prepared for the
question and answer session which will follow the guest lecture.
For a set amount of time each class, students will divide into their groups to discuss the
semester project and pose questions to the instructors. Project checkpoints will also be
required for the 4th, 7th, and 9th weeks of the course to ensure all students are progressing at a
sufficient pace.
Final Project Description
All semester projects include the following:
- 3 project checkpoints
- At minimum, a single page summary of the student’s role within and understanding of
the project.
- A presentation to the class
Project Options:
- (Group) Synthetic Biology Proposals (7-10 pages)
- (Individual) Extended Proposals from Publications Review (3-5 Pages)
A final paper detailing a project proposal for a future synthetic biology project that could
be pursued by the iGEM team.