Team:Tuebingen

From 2014.igem.org

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<h1 >WELCOME TO iGEM 2014! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season!
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:Tuebingen&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<a href="https://2014.igem.org/Team:Tuebingen"style="color:#000000">Home </a> </td>
 
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<a href="https://2014.igem.org/Team:Tuebingen/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=Tuebingen"style="color:#000000"> Official Team Profile </a></td>
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<a href="https://2014.igem.org/Team:Tuebingen/Project"style="color:#000000"> Project</a></td>
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<h1>Tuebingen Erythrocyte Converter to O</h1>
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<a href="https://2014.igem.org/Team:Tuebingen/Parts"style="color:#000000"> Parts</a></td>
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<h4>Welcome to the Wiki of Team Tuebingen!</h4>
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<a href="https://2014.igem.org/Team:Tuebingen/Modeling"style="color:#000000"> Modeling</a></td>
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Erythrocytes (big red balls) have blood group antigens (colourful hexagons) on the surface of their membranes. These antigens consist of glycosilated proteins whereby there are different glycosilations for each blood group. The T-ECO system consists of three bacterial enzymes (blue Pac-Mans) that are able to cut off certain parts of the blood group glycosilations in order to create a blood group O antigen. The enzymes are covalently fused to a matrix (big yellow balls) via SNAP-Tag, SpyTag or inteins in order to prevent a mixing of blood and bacterial proteins.
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<a href="https://2014.igem.org/Team:Tuebingen/Safety"style=" color:#000000"> Safety </a></td>
 
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<p>This year, our project - Tuebingen Erythrocyte Converter to O (T-ECO) - was all about blood and blood transfusions. You might not have known but donor blood is a really rare resource - not only in hospitals in countries with weak medical infrastructure or in crisis regions after natural disasters but also in ordinary Central European hospitals. Due to the fact that humans have at least four different blood groups and two different Rhesus factors - all antigens on erythrocytes - you cannot simply transfuse any blood you want to any random patient. Thus, hospitals do need to always keep an eye on their stocks lest they they are hit by shortages.</p>
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<a href="https://2014.igem.org/Team:Tuebingen/Attributions"style="color:#000000"> Attributions </a></td>
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<p>Therefore, we decided to create a practical and easy to use system for the enzymatic conversion of blood types - from blood types A, B and AB to O. Blood type O consists of erythrocytes that do not show any blood type antigens thus can be transfered to any patient and is usually used as emergency donor blood for exactly this reason.</p>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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<p>Have a look around our wiki and find out more about our <a href="https://2014.igem.org/Team:Tuebingen/Project/Overview">project</a>, the <a href="https://2014.igem.org/Team:Tuebingen/Results/BioBricks">BioBricks</a> we have created, and how we have engaged the general public over the course of this summer!</p>
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<h3>Sponsors</h3>
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<p>We want to warmly thank the following sponsors of our iGEM2014 project (in no particular order): </p>
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    <td><a href="http://www.serva.de/"><img src="https://static.igem.org/mediawiki/2014/2/22/Tue2014_SERVA_logo.jpg"></a></td>
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    <td><a href="http://www.snapgene.com/"><img src="https://static.igem.org/mediawiki/2014/9/9e/Tue2014_Sponsors_SnapGene.png"></a></td>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<li><a href="https://2014.igem.org/Team:Tuebingen">Home</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Team">Team</a> </li>
 
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Tuebingen">Official Team Profile</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Project">Project</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Parts">Parts</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Modeling">Modeling</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Notebook">Notebook</a> </li>
 
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<li><a href="https://2014.igem.org/Team:Tuebingen/Safety">Safety</a> </li>
 
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<td > </td>
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<p>There are a few wiki requirements teams must follow:</p>
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<p>We are currently working on providing teams with some easy to use design templates.
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 03:52, 18 October 2014


Tuebingen Erythrocyte Converter to O

Welcome to the Wiki of Team Tuebingen!

Erythrocytes (big red balls) have blood group antigens (colourful hexagons) on the surface of their membranes. These antigens consist of glycosilated proteins whereby there are different glycosilations for each blood group. The T-ECO system consists of three bacterial enzymes (blue Pac-Mans) that are able to cut off certain parts of the blood group glycosilations in order to create a blood group O antigen. The enzymes are covalently fused to a matrix (big yellow balls) via SNAP-Tag, SpyTag or inteins in order to prevent a mixing of blood and bacterial proteins.

This year, our project - Tuebingen Erythrocyte Converter to O (T-ECO) - was all about blood and blood transfusions. You might not have known but donor blood is a really rare resource - not only in hospitals in countries with weak medical infrastructure or in crisis regions after natural disasters but also in ordinary Central European hospitals. Due to the fact that humans have at least four different blood groups and two different Rhesus factors - all antigens on erythrocytes - you cannot simply transfuse any blood you want to any random patient. Thus, hospitals do need to always keep an eye on their stocks lest they they are hit by shortages.

Therefore, we decided to create a practical and easy to use system for the enzymatic conversion of blood types - from blood types A, B and AB to O. Blood type O consists of erythrocytes that do not show any blood type antigens thus can be transfered to any patient and is usually used as emergency donor blood for exactly this reason.

Have a look around our wiki and find out more about our project, the BioBricks we have created, and how we have engaged the general public over the course of this summer!

Sponsors

We want to warmly thank the following sponsors of our iGEM2014 project (in no particular order):

Retrieved from "http://2014.igem.org/Team:Tuebingen"