Team:Toulouse/Project/Chemotaxis

From 2014.igem.org

(Difference between revisions)
Line 80: Line 80:
   <!--Short description : à changer!!!-->
   <!--Short description : à changer!!!-->
-
<center><img style="width:420px; " src="https://static.igem.org/mediawiki/parts/e/e9/Recap_chemotax.jpg"></center>
 
<p class="title1"> </p>
<p class="title1"> </p>
-
<p class="texte">Coming soon!</p>
+
<p class="texte">
 +
<b>WHAT IS CHEMOTAXIS ?</b>
 +
</br>
 +
Chemotaxis is a bacterial function which allows to bacteria to move according a concentration gradient. This system allows bacteria to find better place to growth, the chemotaxis system is very used by bacteria especially for nutritional molecules like sugar, amino acid, vitamins ...
 +
</p>
 +
 
 +
<p class="texte">
 +
In our case chemotaxis is used as a way to detect and approach fungus. Indeed during its growth, fungi release N-acetylglucosamine, this molecule is the monomer of chitin which is specific to fungal presence. So around fungi there is a gradient of N- acetylglucosamine.</p>
 +
 
 +
<center><img style="width:420px; " src="https://static.igem.org/mediawiki/parts/e/e9/Recap_chemotax.jpg"></center>
 +
 
 +
<p class="texte">
 +
Unfortunately bacillus Subtilis isn’t able to detect such gradient, but bacillus is able to detect and move to sugar like glucose thanks a glucose specific receptor, VcpA. But other bacteria can detect these kind of molecule, for example vibrio cholera, which have a specific receptor for N- acetylglucosamine, VCD.</p>
 +
 
 +
<p class="texte">
 +
Therefore, the idea is pretty simple, we switch glucose specificity by N- acetylglucosamine specificity. So we need to modify the extracellular part of VcpA, the part which is responsible of the specificity, by the extracellular part of a N-acetylglucosamine receptor, VCD.</p>
<p class="title1"> </p>
<p class="title1"> </p>

Revision as of 15:37, 13 October 2014