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Team:TCU Taiwan
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<td align="center"><p><font face="Trebuchet MS" size="6" color="#9FE0F6"><img src="https://static.igem.org/mediawiki/2014/f/f4/TCU-Project-logo.png" width="65"> Project Overview</font></p> | <td align="center"><p><font face="Trebuchet MS" size="6" color="#9FE0F6"><img src="https://static.igem.org/mediawiki/2014/f/f4/TCU-Project-logo.png" width="65"> Project Overview</font></p> | ||
| - | <p align="left"><font size="3" face="Verdana" color="#F3F0CD" >Bacterial resistance to antibiotics has been a problem for public health, and the problem is getting worse.We are trying to develop a CRISPR system combined with phage transduction to solve this problem.<br>The type II CRISPR system is a powerful tool for gene editing, it uses Cas9 protein, which is guided by either a tracrRNA-crRNA or a simplified gRNA, to bind the target gene and creates a double-strand break, therefore knockout the target gene. This system has been proved to have more efficient than other tool such as zinc finger or TALEN. However CRISPR can only function within one cell, so we use M13 phage as vector to send our CRISPR into bacteria cells to remove the antibiotic resistance gene.</font></p> | + | <p align="left"><font size="3" face="Verdana" color="#F3F0CD" >Bacterial resistance to antibiotics has been a problem for public health, and the problem is getting worse.We are trying to develop a CRISPR system combined with phage transduction to solve this problem.<br><br>The type II CRISPR system is a powerful tool for gene editing, it uses Cas9 protein, which is guided by either a tracrRNA-crRNA or a simplified gRNA, to bind the target gene and creates a double-strand break, therefore knockout the target gene. This system has been proved to have more efficient than other tool such as zinc finger or TALEN. However CRISPR can only function within one cell, so we use M13 phage as vector to send our CRISPR into bacteria cells to remove the antibiotic resistance gene.</font></p> |
<p align="center"><img src="https://static.igem.org/mediawiki/2014/9/91/TCU-More-box.png" width="15%"></p></td> | <p align="center"><img src="https://static.igem.org/mediawiki/2014/9/91/TCU-More-box.png" width="15%"></p></td> | ||
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Revision as of 12:50, 2 September 2014
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Bacterial resistance to antibiotics has been a problem for public health, and the problem is getting worse.We are trying to develop a CRISPR system combined with phage transduction to solve this problem.
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Project Overview
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