Team:SCUT/Model/Overview

From 2014.igem.org

(Difference between revisions)
 
(12 intermediate revisions not shown)
Line 4: Line 4:
<head>
<head>
<style type="text/css">
<style type="text/css">
-
body{height:1400px;text-align:center;}
+
body{height:1520px;text-align:center;}
#overview{position:absolute;height:auto;width:100%;top:300px;left:0px;}
#overview{position:absolute;height:auto;width:100%;top:300px;left:0px;}
-
#show p:hover{background-color:#91e5d1;}
+
 
.mainbody1{height:390px;}
.mainbody1{height:390px;}
#over_right{float:right;margin:35px;margin-top:0px;}
#over_right{float:right;margin:35px;margin-top:0px;}
Line 24: Line 24:
<p onclick="scroll_3()">n-butanol part</p>
<p onclick="scroll_3()">n-butanol part</p>
</div>
</div>
-
<div class="navihead navihead2"><a href="https://2014.igem.org/Team:SCUT/Model/Rubisco_simulation"><img src="https://static.igem.org/mediawiki/2014/0/0c/2-01.png"></a>
+
<div class="navihead navihead2"><a href="https://2014.igem.org/Team:SCUT/Model/Rubisco_simulation"><img src="https://static.igem.org/mediawiki/2014/c/c6/Model2-01.png"></a>
</div>
</div>
<div class="navibody navibody2">
<div class="navibody navibody2">
Line 35: Line 35:
</div>
</div>
<div class="navihead navihead3">
<div class="navihead navihead3">
-
<a href="https://2014.igem.org/Team:SCUT/Model/N-butanol_simulation"><img src="https://static.igem.org/mediawiki/2014/1/16/3-01.png"></a>
+
<a href="https://2014.igem.org/Team:SCUT/Model/N-butanol_simulation"><img src="https://static.igem.org/mediawiki/2014/d/d2/Model3-01.png"></a>
</div>
</div>
<div class="navibody navibody3">
<div class="navibody navibody3">
Line 43: Line 43:
</div>
</div>
<div class="navihead navihead5">
<div class="navihead navihead5">
-
<a href="https://2014.igem.org/Team:SCUT/Model/Tips_for_other_teams"><img src="https://static.igem.org/mediawiki/2014/7/7f/5-01.png"></a>
+
<a href="https://2014.igem.org/Team:SCUT/Model/Tips_for_other_teams"><img src="https://static.igem.org/mediawiki/2014/a/af/Model4-01.png"></a>
</div>
</div>
<div class="navibody navibody5">
<div class="navibody navibody5">
Line 61: Line 61:
<p>
<p>
<img src="https://static.igem.org/mediawiki/2014/8/83/Model-outline.PNG" id="over_right">
<img src="https://static.igem.org/mediawiki/2014/8/83/Model-outline.PNG" id="over_right">
-
The design and redesign is one of the hallmarks of synthesis biology. In order to test the consistence of the pathway we designed and the function of scaffold we used, modeling is the most powerful tool to be used before doing experiments.  
+
The design and redesign is one of the hallmarks of synthesis biology. In order to test the consistence of the pathway we designed and the function of scaffold we used, modeling is the most powerful tool to be used before doing experiments.<br/>
</p>
</p>
</div>
</div>

Latest revision as of 15:05, 26 November 2014

Background

The design and redesign is one of the hallmarks of synthesis biology. In order to test the consistence of the pathway we designed and the function of scaffold we used, modeling is the most powerful tool to be used before doing experiments.

Carbon dioxide fixed part

For the carbon dioxide fixed part, we use ODEs (ordinary differential equations) to simulate the pathway and proof the function of RuBisCo. With the help of parameter sweep, we find out the optimal reaction rate ratio of the reactions involved in the scaffold. By the way ,we also use the“bottom-up” strategy, the most famous principle of Computer Science, to guide our work.

n-butanol part

For the n-butanol part, in order to simulate the n-butanol biosynthetic pathway in Saccharomyces cerevisiae mitochondria, we construct a model by using Michealis-Menton kinetics and ODEs (ordinary differential equations). The model shows that, with high concentrations of NADH and NADPH in mitochondria, the production of n-butanol will be greatly improved.

Besides, all of our programs run on the MATLAB.