Team:Oxford/Modelling

From 2014.igem.org

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<h1>Our team believes that the key to synthetic biology is using engineering design and engineering modelling to significantly improve the development of biochemical systems. Therefore, the engineers in our team have worked with the biochemists every step of the way throughout our project to design the initial project ideas, to analyse in detail the expected response of the system and to analyse the results of the various types of experiments that we have run.
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In the emerging field of synthetic biology, iGEM is growing as a source of ambitious and imaginative ideas which have the potential to offer great benefits to human society and our environment. The number of successful iGEM start-ups clearly demonstrates that the competition gives teams the opportunity to get involved in much more than just a summer project; students have the chance to come up with a solution which has a positive impact in the real world.
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In fact, many projects are conceived in the hope of doing just this, often with a specific unresolved social problem in mind. iGEM draws inspiration from the world and the challenges it faces, and contributes back potential solutions.
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This means that, unlike iGEM teams in the past, our modelling is presented interspersed with our biochemistry information to hopefully give a feel of the real interactions that have taken place between the specialities in our team. To aid the viewer, all modelling sections have pink header bubbles, all of the biochemistry sections have light blue header bubbles.
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"Quote from EA about usefulness of our project/bioremediation/synthetic biology generally, the fact that it could actually help the problem etc…”
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(British Environment Agency)
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Our work with the Environment Agency, which inspired us to explore bioremediation as an option for dealing with the pressing environmental concern cause by chlorinated solvent pollution, brought home just how great an impact our own project might have on the in cleaning up this issue. Chlorinated solvents are indispensable to many manufacturing, professional, and even everyday household activities, yet no environmentally acceptable method of disposal currently exists. Our research has led us to believe that bioremediation is a genuinely viable option for addressing this challenge, a position which the Environment Agency has supported. We realized that what began as an iGEM project may well be worth developing further than the months we had to complete the competition.
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We have also worked very closely with the human practices team and influential figures in industry to look at exactly how this project could be implemented in the real world. Included in this has been the 3D CAD of the expected product and the 3D printing and circuit building of the biosensor unit.
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With this in mind, for the policy and practices element of our project we decided to ask…
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Click on the links below to find out more.</h1>
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<h1grey align="center">HOW CAN AN IGEM PROJECT CHANGE THE WORLD?</h1grey>
 
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For the policy and practices element of the competition, our team has researched how iGEM projects grow from ideas into real world solutions. What are the challenges face teams who want to develop their projects beyond the jamboree? What can be done to help them realise the potential benefits of their ideas for society? And what should we be aiming to achieve by all this?
 
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Our team identified what we believe are the key considerations for teams to take into account.
 
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<h1blue3>The Goal….</h1blue3>
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<h1blue3>Characterising a genetic network</h1blue3>
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<h2blue3>Many teams are inspired by their search for a synbio solution to a problem or challenge faced by the world. For our team, the need for a way of address the environmental problems caused by chlorinated solvents was clear. Find out more here...</h2blue3>
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<h2blue3>We used stochastic and deterministic genetic circuit modelling helped the wet-lab team develop the ability to characterise a previously unknown genetic circuit. Find out more here...
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Revision as of 23:37, 20 September 2014

#list li { list-style-image: url("https://static.igem.org/mediawiki/2014/6/6f/OxigemTick.png"); } }


Modelling Homepage


Our team believes that the key to synthetic biology is using engineering design and engineering modelling to significantly improve the development of biochemical systems. Therefore, the engineers in our team have worked with the biochemists every step of the way throughout our project to design the initial project ideas, to analyse in detail the expected response of the system and to analyse the results of the various types of experiments that we have run.

This means that, unlike iGEM teams in the past, our modelling is presented interspersed with our biochemistry information to hopefully give a feel of the real interactions that have taken place between the specialities in our team. To aid the viewer, all modelling sections have pink header bubbles, all of the biochemistry sections have light blue header bubbles.

We have also worked very closely with the human practices team and influential figures in industry to look at exactly how this project could be implemented in the real world. Included in this has been the 3D CAD of the expected product and the 3D printing and circuit building of the biosensor unit.

Click on the links below to find out more.

Characterising a genetic network
We used stochastic and deterministic genetic circuit modelling helped the wet-lab team develop the ability to characterise a previously unknown genetic circuit. Find out more here...
Practicality….
How can the idea be implemented and delivered in the real world? Our engineers used design software and 3D printing to think about how we might realise DCMation and the environments in which the biosensor and bioremediation technique might be used.
Intellectual Property….
Determining the ownership of the intellectual property of a project is crucial for any team hoping to develop their ideas beyond the Jamboree. Our report looks at how the iGEM community can navigate this controversial and difficult issue.
Communication….
Determining the ownership of the intellectual property of a project is crucial for any team hoping to develop their ideas beyond the Jamboree. Our report looks at how the iGEM community can navigate this controversial and difficult issue.
Public Participation….
Determining the ownership of the intellectual property of a project is crucial for any team hoping to develop their ideas beyond the Jamboree. Our report looks at how the iGEM community can navigate this controversial and difficult issue.
The iGEM Competition….
iGEM has been steadily expanding since its beginnings in 2004, climbing from 5 to over 200 teams in the last 10 years. As the first ever Oxford team, we are more than a little late to the party! Our team has researched the growing contribution made by the rest of Europe to the competition, of which we hope to become a part from 2014 onwards!