Team:LMU-Munich

From 2014.igem.org

(Difference between revisions)
Line 1: Line 1:
{{Template:Team:LMU-Munich/Header}}
{{Template:Team:LMU-Munich/Header}}
<html>
<html>
-
<br />
+
<img src="http://www.fanaru.com/doge/image/18361-doge-follow-your-dreams.jpg" width=980 height=400></img>
-
<p>
+
</html>
-
<img src="http://www.fanaru.com/doge/image/18361-doge-follow-your-dreams.jpg" width=960 height=400></img>
+
-
</p></html>
+

Revision as of 09:27, 3 September 2014


„BaKillus“ – Engineering a pathogen-hunting microbe

WOW

Doge

Increasing bacterial resistance to classical antibiotics remains a serious threat and urges the development of novel pathogen-killing strategies. Exploiting bacterial communication mechanisms such as quorum sensing is a promising strategy to specifically target certain pathogens. The major aim of this project is the introduction of a genetic circuit enabling Bacillus subtilis to actively detect, attach to, and eventually kill Staphylococcus aureus and Streptococcus pneumoniae. Initially, we will introduce the autoinducer-sensing two-component systems of S. aureus and S. pneumoniae into B. subtilis. to create a pathogen-detecting strain. By utilizing quorum sensing-dependent promoters, we will then trigger pathogen-killing strategies like the production of antimicrobial peptides or biofilm degradation. As a safety measure a delayed suicide-switch guarantees non-persistence of genetically modified B. subtilis in the absence of pathogens. We envision the use of BaKillus as a smart, cheap and simple-to-use medical device for diagnostics and targeted treatment of multiresistant superbugs.


SUCH IGEM!

panel discussion