Team:Freiburg/Content/Project/Outlook

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<h1>Outlook</h1>
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<p>The AcCELLerator, while still in its infancy, might soon proof to be an asset in various areas. First of all, it can provide a powerful tool for the rapid generation of stable cell lines. The AcCELLerator can deliver different gene cargos ranging from orthogonal gene cargos, transcriptional activators or even modern genome engineering tools like the CRISPR/Cas system. &nbsp;In combination with a vector library comparable to a conventional DNA library it would be possible to express a certain gene within a couple of days. Such a library could accelerate basic research, especially when different genes have to be expressed with a high temporal and spatial resolution. </p></div>
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<p>These properties are predistined to be used in the field of tissue engineering or synthetic production of biomaterials. In a tissue or biomaterial all cells have to express a distinct subset of genes; deficient gene expression &nbsp;would lead to abnormalities and cancer. Therefore a highly specific gene delivery is mandatory.</p><p>As the potential applications are numerous and as it is not possible to optimize the system completely in the course of only one iGEM project, we encourage the community&nbsp; to use and improve the AcCELLerator!</p>
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<h1>Outlook</h1>
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<p>Our new application, <em>The AcCELLerator</em>, can have great impact on basic research. Creating only one transgenic model organism with the light-inducible receptor will enable introduction of any gene of interest via the MuLV in a highly specific, spatio-temporally resolved manner. 
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In combination with modern genome engineering tools like  CRISPR/Cas9, The AcCELLerator will be a powerful tool for creating tissue specific and temporally regulated knock-outs.
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These properties are predestined to be used in the field of tissue engineering or synthetic production of biomaterials. In a tissue or biomaterial all cells have to express a distinct subset of genes; deficient gene expression  would lead to abnormalities and cancer.</p>
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The AcCELLerator can further provide a powerful tool for the rapid generation of stable cell lines.  In combination with the powerful iGEM registry, where we introduced the pMIG backbone for viral delivery, it would be possible to stably express all available genes within a couple of days.
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As the potential applications are numerous and as it is not possible to optimize the system completely in the course of only one iGEM project, we encourage the community  to use and improve <em>The AcCELLerator</em>!
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<h1>Project</h1>
 
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<li><a href ="/Team:Freiburg/Project/Overview">Overview</a></li><li>
 
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<a href ="/Team:Freiburg/Project/The_light_system">The light system</a></li><li>
 
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<a href ="/Team:Freiburg/Project/The_viral_vector">The viral vector</a></li><li>
 
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<a href ="/Team:Freiburg/Project/The_combination">The combination</a></li><li>
 
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<a href ="/Team:Freiburg/Project/Outlook">Outlook</a></li><li style = "border-bottom: 4px solid #007A7A;">
 
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Latest revision as of 03:56, 18 October 2014

The AcCELLerator

Outlook

Our new application, The AcCELLerator, can have great impact on basic research. Creating only one transgenic model organism with the light-inducible receptor will enable introduction of any gene of interest via the MuLV in a highly specific, spatio-temporally resolved manner. In combination with modern genome engineering tools like CRISPR/Cas9, The AcCELLerator will be a powerful tool for creating tissue specific and temporally regulated knock-outs. These properties are predestined to be used in the field of tissue engineering or synthetic production of biomaterials. In a tissue or biomaterial all cells have to express a distinct subset of genes; deficient gene expression would lead to abnormalities and cancer.

The AcCELLerator can further provide a powerful tool for the rapid generation of stable cell lines. In combination with the powerful iGEM registry, where we introduced the pMIG backbone for viral delivery, it would be possible to stably express all available genes within a couple of days. As the potential applications are numerous and as it is not possible to optimize the system completely in the course of only one iGEM project, we encourage the community to use and improve The AcCELLerator!