Team:ETH Zurich/project/infopro

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(The goal: Pattern emergence via information processing)
(The goal: Emergence of patterns via information processing)
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=== The goal: Emergence of patterns via information processing===
=== The goal: Emergence of patterns via information processing===
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We implement a cellular automaton in bacterial colonies. Each bacterial colony is a core, computing an XOR gate. A sensor device detects the inputs, HSL molecules. Then, the cell integrates the signal through a logic gate, performed by proteins, the serine integrases. A necessary post processing step generates the production of HSL molecules. Meanwhile, GFP, a visual read out, longlastingly indicates the state of the well. The produced signal then propagates in a directive fashion through a millifluidic chip. This iterative process faces the challenges of leakiness, cross-talk, protein-level computation and diffusion.
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We implement a cellular automaton with bacterial cells containing our logic circuitry. Each bacterial colony serves as a core, computing an XOR gate. First, a sensor device detects the input, ''N''-acyl homoserine lactones (AHL). Then, the cell integrates this signal through a logic gate, performed by serine integrases on the protein level. A necessary post-processing step allows the production of new AHL variant. Meanwhile, green fluorescent protein (GFP) indicates the state of the colony and serves as a long-lasting visual read out. The produced AHL output-signal then propagates in a directed fashion through a millifluidic grid to the next bacterial colony. This iterative process faces the challenges of leakiness, cross-talk, protein-level computation and exact diffusion steps.
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[[File:ETH_Zurich2014_info_processing1.png|center|800px|thumb|'''Figure 1'''The information pathway in the project Mosai''coli'' on a colony level.]]
[[File:ETH_Zurich2014_info_processing1.png|center|800px|thumb|'''Figure 1'''The information pathway in the project Mosai''coli'' on a colony level.]]

Revision as of 02:17, 18 October 2014

iGEM ETH Zurich 2014