Team:ETH Zurich/project/applications

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==Biocomputation==
==Biocomputation==
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Future development of synthetic biological systems will require the implementation of reliable synthetic circuits. These genetic circuits will be designed to program new biological behaviour, dynamics, and logic control<sup>[[Team:ETH_Zurich/project/references#refWeiss|[1]]]</sup>. A well established multichannel orthogonal communication system is crucial for efficient biological computation which is subsequently required for the performance of the cells tasks. In order to achieve the goals of our project we need to thoroughly characterise available components, improve their performance, and develop novel constructs for robust multichannel orthogonal communication and subsequent logic processing. With our findings we will try to make a contribution to the field of biological computation by enabling further development of complex systems that depend on the interaction between its sub components.
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Future development of synthetic biological systems will require the implementation of reliable synthetic circuits. These genetic circuits will be designed to program new biological behaviour, dynamics, and logic control<sup>[[Team:ETH_Zurich/project/references#refWeiss|[1]]]</sup>. A well established multichannel orthogonal communication system is crucial for efficient biological computation which is subsequently required for the performance of the cells tasks. In order to achieve the goals of our project we need to thoroughly characterise available components, improve their performance, and develop novel constructs for robust multichannel orthogonal communication and subsequent logic processing. With our findings we will try to make a contribution to the field of biological computation by enabling further development of complex systems that depend on the interaction between its subcomponents.
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==Alginate-Microencapsulated Implants==
==Alginate-Microencapsulated Implants==
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[[File:ETH_Zurich_2014_Application_implant.png|center|750px|frame|Modular therapeutic alginate-microencapsulated implants which communicate on orthogonal channels. Each module can be exchanged or separately updated depending on the disease.]]
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[[File:ETH_Zurich_2014_Application_implant.png|center|frame|500px|thumb|'''Figure 1''' Modular therapeutic alginate-microencapsulated implants which communicate on orthogonal channels. Each module can be exchanged or separately updated depending on the disease.]]
==3D-Printing in Biology==
==3D-Printing in Biology==
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[[File:ETH_Zurich_2014_final_mold.jpeg|height=300px]][[File:ETH_Zurich_2014_PDMS_diffusion_chip_final.jpeg|height=300px]]
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{|
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|[[File:ETH_Zurich_2014_final_mold.jpeg|461px|thumb|'''Figure 2''' ABS based mold as template for a PDMS millifluidic chip]]
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|[[File:ETH_Zurich_2014_PDMS_diffusion_chip_final.jpeg|400px|thumb|'''Figure 3''' PDMS millifluidic chip from ABS mold compatible with common microtiter plate readers]]
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"You envision something, draw it with the right software, and then print it in three dimensions—regardless of how many parts it has, how they interlock, or whether they will even be accessible once your creation is completed. With this strategy, anyone can make almost anything"<sup>[[Team:ETH_Zurich/project/references#refWallich|[36]]]</sup>. In more production oriented, classical engineering disciplines this vision of additive manufacturing and rapid prototyping is already established as an useful standard application. However, the technology is also valuable for production of custom made laboratory equipment<sup>[[Team:ETH_Zurich/project/references#refKitson|[31]]]</sup>, in particular in more technology oriented sub-disciplines such as synthetic biology. We have shown the feasibility of 3D-printing for microtiter plates and mold production and make the files available for other applications via the [http://3dprint.nih.gov/ NIH 3D Print Exchange].
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Latest revision as of 23:18, 17 October 2014

iGEM ETH Zurich 2014