Team:EPF Lausanne

From 2014.igem.org

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<p class="lead">The biological concepts behind the BioPad project have applications in basic and applied sciences. From a scientific perspective, the ideas introduced and implemented by our project are novel and promising for future applications. The BioPad is also an interesting concept that will encourage public awareness of synthetic biology. The tangibility of the project will allow the general public to look at synthetic biology in a better way as people will understand how great genetically modified organisms are ! To conclude, the combination of novel biological concepts, a cool idea, and the community awareness that our project provides, makes the BioPad project perfect an ideal project for iGEM !
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<p class="lead">The biological concepts behind the BioPad project have applications in basic and applied sciences. From a scientific perspective, the ideas introduced and implemented by our project are novel and promising for future applications. The BioPad is also an interesting concept that will encourage public awareness of synthetic biology. The tangibility of the project will allow the general public to look at synthetic biology in a better way as people will understand how great genetically modified organisms are ! To get down the basics, the combination of novel biological concepts, a cool idea, and the community awareness that our project provides, makes the BioPad project perfect an ideal project for iGEM !
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Revision as of 17:25, 6 October 2014

Our project in a nutshell


Summary of our Project

EPFL_interaction_IFP_cartoon

The 2014 EPFL iGEM team has been working on showing that biologically engineered organisms can detect and process signals quickly and efficiently. With this in mind, our team brought forward a novel idea: combining Protein Complementation techniques with biosensors to achieve fast spatiotemporal analysis of bacterial response to stimuli.

As a proof-of-concept, we aimed to develop the first BioPad: a biological TouchPad made of touch- responsive bacteria in a microfluidic chip allowing the control of electronic devices. This was achieved by engineering the E.Coli Cpx Pathway– a two- component regulatory system that is responsive to periplasmic stress.

Why a BioPad?

Microfluidics

The biological concepts behind the BioPad project have applications in basic and applied sciences. From a scientific perspective, the ideas introduced and implemented by our project are novel and promising for future applications. The BioPad is also an interesting concept that will encourage public awareness of synthetic biology. The tangibility of the project will allow the general public to look at synthetic biology in a better way as people will understand how great genetically modified organisms are ! To get down the basics, the combination of novel biological concepts, a cool idea, and the community awareness that our project provides, makes the BioPad project perfect an ideal project for iGEM !


The BioPad's Applications

The BioPad system demonstrates that protein complementation techniques are suitable for biosensor applications – especially for two-component regulatory systems. The introduction of the split IFP1.4 into the registry will allow future iGEM research teams to take advantage of the reversibility and precision of this protein. Moreover, our work on the Cpx pathway will allow future iGEM teams to make novel uses of other members of the OmpR/PhoB subfamily, as well as other two-component regulatory systems.

The BioPad could potentially be used to deliver a cheap, efficient and accurate antibiotic screening system that allows researchers to easily quantify the effects of antibiotics on periplasm in gram-negative bacteria. The BioPad project could also provide a new approach to studying genes by allowing researchers to the examine the relationship between genes and their corresponding activating signals.

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Stress responsive bacteria


touch bacteria

This is a description

Microfluidics

Our Biopad is implemented in a microfluidic chip. This tool allows all kinds of analytical experiments and is increasingly used in biological research. From fabrication to applications, find out more about this awesome device here!

Yeast

description

I.T

description

Human practice

description

MEET OUR TEAM

We are a group of 14 students from the faculties of Life, Biomechanical, and Computer Sciences, and are supervised by 2 EPFL professors, 1 Lecturer and 5 PhD students.

the team's students

Sponsors