Team:Brasil-SP
From 2014.igem.org
WELCOME TO iGEM 2014!Your team has been approved and you are ready to start the iGEM season!
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Project DescriptionOur project consists of a biological molecular device (using Bacillus subtilis as chassis) for detection of Cystatin C, a biomarker of chronic kidney disease. The genetic circuit being assembled is based on the outstanding project of the Imperial College of London team of iGEM 2010 (special thanks to the ex-iGEMer Christopher Hirst, who helped us a lot sending some important BioBricks to us). Part of our mission is also to improve the characterization of the BioBricks developed on 2010 and to validate the molecular design as a generic detection system. This flexibility of detection is based on a protease cleavage of a membrane protein who triggers the genetic circuit. Since any cleavage site could be designed, virtually any protease could be used as a signal for the detection. In our case, the disease biomarker will inhibit the action of our chosed protease (Cathepsin S) and the detection will be made indirectlly and negativelly - i.e. by the Cathepsin lack of protease activity and absense of the system output. We're on the way to assemble all the parts and properlly characterize each part of our construction on time for the Jamboree. |
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Wiki Pre Structure (Under Construction!)This is the initial wiki pre structure that might be changed over its development. Everything here is merely provisional!
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Requirements | ||||||||||||
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Tips | ||||||||||||
We are currently working on providing teams with some easy to use design templates.
For a full wiki list, you can visit iGEM 2013 web sites and iGEM 2012 web sites lists. |
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