Team:NEAU-Harbin/background.html

• Background
• Design
• Application
• Dry lab

Aspergillus niger is one of the most common fungus species of the genus Aspergillus. It can produce more than 30 kinds of enzyme products such as amylase, acid protease, cellulase, pectinase and glucose oxidase, and has been applied in the field of food production for a long time.

Due to its high expression and secretory capacity, A. niger has a long tradition in the production of enzymes and organic acids. Many of these products have obtained GRAS (generally regarded as safe) status, and are widely used in biotechnology for the production of food ingredients, pharmaceuticals and industrial enzymes.

Comparing to E. coli, eukaryotic post-translational protein processing machinery of A. niger is an added bonus, with a view of using fungi as expression hosts for proteins requiring elaborate posttranslational modification – for example, in the form of protein glycosylation, proteolytic cleavage or formation of multiple disulfide bonds.