Team:TCU Taiwan/Team

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  <span><p>ipsc</p>
 
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<a href="https://2014.igem.org/Team:TCU_Taiwan"style="color:#ffffff"><font size="5">Home </font></a> </td>
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Team"style="color:#ffffff"><font size="5">Team</font></a> </td>
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<span>Project/Overview</span>
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<h1>Overview: iPSCs Safeguard</h1>
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<p>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=TCU_Taiwan"style="color:#ffffff"><font size="5">Official Team Profile</font></a></td>
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<strong>To live or not to live?</strong> This time, why not let cells answer this question and select their fates automatically?
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<br /><img src=" https://static.igem.org/mediawiki/2013/9/90/Overview1.png " width="700" /><br />
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Project"style="color:#ffffff"><font size="5">Project</font></a></td>
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This summer, iGEM team of SYSU-China came up with a new strategy to minimize the tumorigenesis risks of iPSCs: We designed a device which can <strong>select the right kinds of cells from induced cell mass and retain selection pressure to remove cancerous cells in the long term.</strong> During differentiation, undifferentiated cells or wrong kinds of differentiated cells will undergo apoptosis and the transferred cells can be cultured and brought into further usage. After cells are transplanted into patient’s body, the spontaneous cancerous cells can be killed and cleared.  
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Parts"style="color:#ffffff"><font size="5">Parts</font></a></td>
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Modeling"style="color:#ffffff"><font size="5">Modeling</font></a></td>
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Safety"style=" color:#ffffff"><font size="5">Safety</font></a></td>
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<a href="https://2014.igem.org/Team:TCU_Taiwan/Attributions"style="color:#ffffff"><font size="5">Attributions</font></a></td>
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<td align ="center"> <a href="https://2014.igem.org/Main_Page"> <img src="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png" width="55px"></a> </td>
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We have chosen <strong>hepatocytes</strong>, a type of normal liver cell, and its highly expressed miR-122 to achieve this idea. In order to accurately control our device at the right time, we introduced a manually-indusing switch, tet-off system, to our project. We altered promoter of gene into EF-1α which would not be silenced in pluripotent stage. There are several ways to convert iPS cells into hepatocytes available. We hope that our device could promote the development and clinical application of iPSC technology.  
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<p><strong>So... To live or not to live? </strong></p>
 
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<p>
 
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We prefer:
 
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<strong><h1>To liver or not to live!</h1></strong>
 
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</p>
 
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<h3>Tell us about your team! </h3>
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<DIV id="address"><p>Sun Yat-Sen University, Guangzhou, China</p><p>Address: 135# Xingang Rd.(W.), Haizhu Guangzhou, P.R.China</p></DIV> 
 
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<td width="20%"><p>Team Member Profile<br> Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. </p></td>
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<td width="30%"><p>  Instructor Profile <br> Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an. </p></td>
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Home Team Official Team Profile Project Parts Modeling Notebook Safety Attributions

Tell us about your team!

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Students Instructors Advisors

Students

Team Member Profile
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Team Member Profile
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Team Member Profile
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Team Member Profile
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Instructors

Instructor Profile
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Instructor Profile
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Instructor Profile
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Advisors

Advisor Profile
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Advisor Profile
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Advisor Profile
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Advisor Profile
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