Team:UFMG Brazil

From 2014.igem.org

(Difference between revisions)
Line 13: Line 13:
<div id="portfolio" class="container">
<div id="portfolio" class="container">
<div class="title">
<div class="title">
-
<h5>Team</h5></div>
+
<h5>Team</h5>
-
<div class="column1">
+
<span class="byline"><a href='#' class="button button-big"> Meet us all! </a> </div>
 +
<div class="column1">
<div class="box"><img src="https://static.igem.org/mediawiki/2014/4/41/Liza.jpg" alt="" class="image image-full" />
<div class="box"><img src="https://static.igem.org/mediawiki/2014/4/41/Liza.jpg" alt="" class="image image-full" />
-
<h6>Liza Felicori</h6>
+
<h5>Liza Felicori</h5>
-
<p></p>
+
<p>Fermentum nibh augue praesent a lacus at urna congue rutrum.</p>
<a href="#" class="button button-small">Know More</a> </div>
<a href="#" class="button button-small">Know More</a> </div>
</div>
</div>
<div class="column2">
<div class="column2">
<div class="box"><img src="https://static.igem.org/mediawiki/2014/a/a1/Rafa1.jpg" alt="" class="image image-full" />
<div class="box"><img src="https://static.igem.org/mediawiki/2014/a/a1/Rafa1.jpg" alt="" class="image image-full" />
-
<h6>Rafaela</h6>
+
<h5>Rafaela</h5>
-
<p></p>
+
<p>Vivamus fermentum nibh in augue praesent urna congue rutrum.</p>
<a href="#" class="button button-small">Know More</a> </div>
<a href="#" class="button button-small">Know More</a> </div>
</div>
</div>
<div class="column3">
<div class="column3">
<div class="box"><img src="https://static.igem.org/mediawiki/2014/3/35/Clara.jpg" alt="" class="image image-full" />
<div class="box"><img src="https://static.igem.org/mediawiki/2014/3/35/Clara.jpg" alt="" class="image image-full" />
-
<h6>Clara Guerra</h6>
+
<h5>Clara Guerra</h5>
-
<p></p>
+
<p>Vivamus fermentum nibh in augue praesent urna congue rutrum.</p>
<a href="#" class="button button-small">Know More</a> </div>
<a href="#" class="button button-small">Know More</a> </div>
</div>
</div>
<div class="column4">
<div class="column4">
<div class="box"><img src="https://static.igem.org/mediawiki/2014/9/93/Rodrigo.jpg" alt="" class="image image-full" />
<div class="box"><img src="https://static.igem.org/mediawiki/2014/9/93/Rodrigo.jpg" alt="" class="image image-full" />
-
<h6>Rodrigo</h6>
+
<h5>Rodrigo</h5>
-
<p></p>
+
<p>Rutrum fermentum nibh in augue praesent urna congue rutrum.</p>
<a href="#" class="button button-small">Know More</a> </div>
<a href="#" class="button button-small">Know More</a> </div>
</div>
</div>
</div>
</div>
</div>
</div>
 +
<div id="wrapper4">
<div id="wrapper4">

Revision as of 14:48, 7 October 2014

Home

Welcome to our wiki

Colorectal cancer includes tumors affecting a segment of the large intestine (colon) and rectum. It is treatable and, in most cases, curable when detected early, before it hasn't spread to other organs. However, the diagnosis requires a biopsy, made ​​by handset introduced via rectum. Noticeably, this procedure is highly invasive and often inhibits patients to submit to this practice, hampering the discovery of cancer at an early stage and thereby reducing the chances of effective treatment and cure. On our institution, a modified probiotic strain of Saccharomyces cerevisiae was isolated from local beverage. Our objective is to introduce this strain as a new probiotic chassis on iGEM, and also to develop a gene circuit that allows it to detect one or more stool biomarkers for colorectal cancer on the intestine and report with a color change on the feces. We chose L-DNA (long DNA molecules) as biomarker, and designed a chimeric protein using TALE DNA-Binding Domains and a split version of mCherry. This protein can detect certain repetitive sequences on DNA and emit red fluorescence, which when measured serve as proxy for the DNA size. Since RFP emission falls on the visible spectrum, it can also be used for staining the feces, allowing for a patient consuming the probiotic to become aware of the possibility of the developing problem just by checking on the color of their stool.

Know More
Liza Felicori

Fermentum nibh augue praesent a lacus at urna congue rutrum.

Know More
Rafaela

Vivamus fermentum nibh in augue praesent urna congue rutrum.

Know More
Clara Guerra

Vivamus fermentum nibh in augue praesent urna congue rutrum.

Know More
Rodrigo

Rutrum fermentum nibh in augue praesent urna congue rutrum.

Know More