Team:MIT

From 2014.igem.org

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<table width=95% align=center>
<table width=95% align=center>
<tr><td><h3 style="font-size:20px" align=center>Improving the Diagnosis and Treatment of</h3></td></tr>
<tr><td><h3 style="font-size:20px" align=center>Improving the Diagnosis and Treatment of</h3></td></tr>
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<tr><td><h3 style="font-size:45px" align=center>ALZHEIMER'S DISEASE</h3></td></tr>
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<tr><td><h3 style="font-size:50px" align=center>ALZHEIMER'S DISEASE</h3></td></tr>
<tr><td><h3 style="font-size:25px" align=right></h3></td></tr>
<tr><td><h3 style="font-size:25px" align=right></h3></td></tr>
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<tr><td><p align=left>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.<br>
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<tr><td><p align=left>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems…  There is currently no cure for this disease, and existing diagnosis methods leave much to be desired.  MIT iGEM 2014 has set out to change this.  By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease.  Looking ahead, … delivery.</p></td></tr>
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DETECT TREAT DELIVER</p></tr></td>
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<tr><td><h3 style="font-size:35px" align=center><u>DETECTION    TREATMENT    DELIVERY</u></h3></td></tr>
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<tr><td><br></td></tr>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e9/MIT_Native_receptor_homepage.png"><br>Natural AB receptor</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/e/e9/MIT_Native_receptor_homepage.png"><br><p style="font-size:15px">Native beta-amyloid receptor</p></td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/f/f8/MIT_bcr_homepage.png"><br>Engineered AB receptor</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/f/f8/MIT_bcr_homepage.png"><br><p style="font-size:15px">Engineered B-cell receptor</p></td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/8/88/MIT_mirna_homepage.png"><br>Sensors for Alzheimer’s state</td>
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<td width=33.3%><img src="https://static.igem.org/mediawiki/2014/8/88/MIT_mirna_homepage.png"><br><p style="font-size:15px">miRNA sensors for Alzheimer’s state</p></td>
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<td width=50%><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"></td>
<td width=50%><img src="https://static.igem.org/mediawiki/2014/0/06/MIT_future_homepage.png"></td>
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<tr><td>Regulate AB production<br> and degradation</td>
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<tr><td><p style="font-size:15px">Regulating beta-amyloid production<br> and degradation</p></td>
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<td>Ways to deliver our circuit </td>
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<td><p style="font-size:15px">Delivering our circuit</p> </td>
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</table>

Revision as of 06:34, 15 October 2014

 


Image Map



Improving the Diagnosis and Treatment of

ALZHEIMER'S DISEASE

[Dying Neuron]
Neurodegenerative Disease
[6th]
Leading cause of death in the US
[Vaccine]
Current diagnosis and therapeutics are not effective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.

DETECTION → TREATMENT → DELIVERY


DETECTION


Native beta-amyloid receptor


Engineered B-cell receptor


miRNA sensors for Alzheimer’s state


TREATMENT

DELIVERY

Regulating beta-amyloid production
and degradation

Delivering our circuit